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What is Zerograin Plus?

Zerograin Plus Tablet is used for Headache, Migraine, Tooth ache, Migraine attacks, Ear pain, Cephalalgia and other conditions. Zerograin Plus Tablet may also be used for purposes not listed in this medication guide.
Zerograin Plus Tablet contains Domperidone, Flunarizine and Paracetamol as active ingredients.
Zerograin Plus Tablet works by blocking the dopamine receptors; blocking the entry of calcium through calcium channels; increasing the pain threshold and increases the blood flow across the skin, heat loss and sweating;
Mankind Pharma manufactures Zerograin Plus Tablet.
Detailed information related to Zerograin Plus Tablet's uses, composition, dosage, side effects and reviews is listed below.

Zerograin Plus Tablet Uses

Zerograin Plus Tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
References: 1, 2, 3, 4
Learn more: Uses

Zerograin Plus Tablet Working, Mechanism of Action and Pharmacology

Zerograin Plus Tablet improves the patient's condition by performing the following functions:
  • Blocking the dopamine receptors.
  • Blocking the entry of calcium through calcium channels.
  • Increasing the pain threshold and increases the blood flow across the skin, heat loss and sweating.
References: 1, 3, 5

Zerograin Plus Tablet - Composition and Active Ingredients

Zerograin Plus Tablet is composed of the following active ingredients (salts)
Please note that this medicine may be available in various strengths for each active ingredient listed above.

Zerograin Plus Tablet - Side-effects

The following is a list of possible side-effects that may occur from all constituting ingredients of Zerograin Plus Tablet. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
References: 1, 3, 5
Learn more: Side-effects

Zerograin Plus Tablet - Precautions & How to Use

Before using Zerograin Plus Tablet, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
  • Avoid driving or operating machinery
  • Avoid using it if allergic to paracetamol
  • Concurrent use with QT prolongating agents
  • Discontinue use if experiencing signs or symptoms associated with cardiac arrhythmia
  • Do not drive or operate heavy machinery
  • Do not take paracetamol if you consume alcoholic beverages every day
References: 1, 1, 3, 3

Zerograin Plus Tablet - Drug Interactions

If you use other drugs or over the counter products at the same time, the effects of Zerograin Plus Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Zerograin Plus Tablet may interact with the following drugs and products:
  • Alcohol
  • Amiodarone
  • Amprenavir
  • Antacids
  • Aprepitant
  • Atazanavir
References: 1, 3
Learn more: Interactions

Zerograin Plus Tablet - Contraindications

Hypersensitivity to Zerograin Plus Tablet is a contraindication. In addition, Zerograin Plus Tablet should not be used if you have the following conditions:
  • Autosomal dominant metabolic disorder
  • Breastfeeding
  • Co-administration with potent CYP3A4 inhibitors
  • Concomitant use with medicines that prolong the QT interval
  • Congestive heart failure
  • Depression
References: 1, 3
Learn more: Contraindications

Where to Buy Zerograin Plus Tablet

Click here to find nearby pharmacies/medical stores where you can buy Zerograin Plus Tablet.

Zerograin Plus Tablet - Frequently asked Questions

  • Is Zerograin Plus Tablet safe to consume or apply when pregnant?
    • Domperidone: Please consult with your doctor for case-specific recommendations.
    • Flunarizine: No
    • Paracetamol: Please consult with your doctor for case-specific recommendations.
    References: 1 3
  • Is Zerograin Plus Tablet safe while breastfeeding?
    • Domperidone: No
    • Flunarizine: No
    • Paracetamol: Please discuss the risks and benefits with your doctor.
    References: 1 3
  • Can Zerograin Plus Tablet be used for headache and migraine?
    Yes, headache and migraine are among the most common reported uses for Zerograin Plus Tablet. Please do not use Zerograin Plus Tablet for headache and migraine without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Zerograin Plus Tablet.
  • How long do I need to use Zerograin Plus Tablet before I see improvement of my conditions? website users have reported same day and within 2 hours as the most common time it takes before they saw improvements in their conditions. These times may not be reflective of what you may experience or how you should use this medicine. Please consult with your doctor to check how long do you need to use Zerograin Plus Tablet. Click here and view survey results to find out what other patients report as time for effectiveness for Zerograin Plus Tablet.
  • At what frequency do I need to use Zerograin Plus Tablet? website users have reported once a day and twice a day as the most common frequency of using Zerograin Plus Tablet. Please follow your doctor's advice on how often you need to Zerograin Plus Tablet. Click here and view survey results to find out what other patients report as frequency of using Zerograin Plus Tablet.
  • Should I consume Zerograin Plus Tablet empty stomach, before food or after food? website users have most commonly reported consuming Zerograin Plus Tablet after food. However, this may not be reflective of how you should consume this medicine. Please follow your doctor's advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Zerograin Plus Tablet.
  • Is it safe to drive or operate heavy machinery when consuming?
    If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Zerograin Plus Tablet medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Zerograin Plus Tablet. Always consult with your doctor for recommendations specific to your body and health conditions.
  • Is this medicine or product addictive or habit forming?
    Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
  • Can it be stopped immediately or do I have to slowly ween off consumption?
    Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

Other important Information on Zerograin Plus Tablet

Missing a dose

In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
References: 6, 7, 8, 9

Overdosage of Zerograin Plus Tablet

  • Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Zerograin Plus Tablet, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
  • Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
  • Please consult your physician or pharmacist or product package for more information.
References: 10, 11, 12

Storage of Zerograin Plus Tablet

  • Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
  • Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Zerograin Plus Tablet.
References: 13, 14, 15, 16

Expired Zerograin Plus Tablet

  • Taking a single dose of expired Zerograin Plus Tablet is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
References: 17, 18

Dosage Information

Please consult your physician or pharmacist or refer to product package.

Questions - Zerograin Plus Tablet

No questions have been asked.

News and Updates

Latest news and updates related to Zerograin Plus Tablet. Subscribe to get latest posts via email or subscribe to a RSS feed.
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Zerograin Plus Tablet - Packages and Strengths

Zerograin Plus Tablet is available in the following packages and strengths
Zerograin Plus Tablet - Packages: 10 Tablet
Zerograin Plus Tablet - Strengths: 10MG+5MG+325MG

Zerograin Plus Tablet - Manufacturers

The medicine is manufactured by the following companies

Zerograin Plus Tablet - Demographic Information


  1. Package insert. MOTILIUM 10 mg Tablets. Accessed 12/18/2016. - Accessed: October 12, 2016.
  2. Amery, WK (1983). "Flunarizine, a calcium channel blocker: A new prophylactic drug in migraine". Headache. 23 (2): 70–4. doi:10.1111/j.1526-4610.1983.hed2302070.x. PMID 6343298. - Accessed: October 12, 2016.
  3. Dinnendahl, V, Fricke, U, eds. (2012). "Arzneistoff-Profile" (in German). 2 (26 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3. - Accessed: October 12, 2016. (Accessed on 1/3/17)
  4. DailyMed LABEL: ACETAMINOPHEN - acetaminophen tablet, coated - Accessed: October 12, 2016.
  5. Pubchem Acetaminophen - Accessed: October 12, 2016.
  6. - Accessed: July 14, 2016.
  7. - Accessed: July 3, 2016.
  8. Cancer.Net (2014). - Accessed: July 3, 2016.
  9. Schachter, S.C., Shafer, P. O. &; Sirven, J.I. (2013). - Accessed: May 28, 2016.
  10. National Institute of Drug Abuse (2010). - Accessed: July 21, 2016.
  11. eMedicinehealth (2016). - Accessed: July 21, 2016.
  12. Centers for Disease Control and Prevention (2010). - Accessed: July 21, 2016.
  13. Centers for Disease Control and Prevention. December 12, 2011. - Accessed: June 10, 2016.
  14. The Center for Improving Medication Management and the National Council on Patient Information and Education. - Accessed: June 10, 2016.
  15. U.S. Food and Drug Administration. December 24, 2013. - Accessed: June 10, 2016.
  16. World Health Organization: - Accessed: July 1, 2016.
  17. Lyon, R. C., Taylor, J. S., Porter, D. A., et al. (2006) Stability profiles of drug products extended beyond labeled expiration dates. Journal of Pharmaceutical Sciences; 95:1549-60 - Accessed: July 3, 2016.
  18. Harvard Medical School (2016). - Accessed: May 1, 2016.

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APA Style Citation

  • Zerograin Plus Tablet - Uses, Side-effects, Reviews, and Precautions - Mankind Pharma - - India. (n.d.). Retrieved January 21, 2018, from

MLA Style Citation

  • "Zerograin Plus Tablet - Uses, Side-effects, Reviews, and Precautions - Mankind Pharma - - India" N.p., n.d. Web. 21 Jan. 2018.

Chicago Style Citation

  • "Zerograin Plus Tablet - Uses, Side-effects, Reviews, and Precautions - Mankind Pharma - - India" Accessed January 21, 2018.

Last updated date

This page was last updated on 1/19/2018.
This page provides information for Zerograin Plus Tablet in English.
Read Reviews » Zerograin Plus Tablet

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