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What is Silvadene?

Silvadene Cream is used for Burn infection, Topical antimicrobial agent and other conditions. Silvadene Cream may also be used for purposes not listed in this medication guide.
Silvadene Cream contains Silver Sulfadiazine as an active ingredient.
Silvadene Cream works by works on the cell membrane and the cell wall and inhibits various bacterial metabolic processes.
King Pharms manufactures Silvadene Cream.
Detailed information related to Silvadene Cream's uses, composition, dosage, side effects and reviews is listed below.

Silvadene Cream Uses

Silvadene Cream is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
  • Burn infection
  • Topical antimicrobial agent
  • Silvadene Cream may also be used for purposes not listed here.
References: 1
Learn more: Uses

Silvadene Cream Working, Mechanism of Action and Pharmacology

Silvadene Cream improves the patient's condition by performing the following functions:
References: 2

Silvadene Cream - Composition and Active Ingredients

Silvadene Cream is composed of the following active ingredients (salts)
Please note that this medicine may be available in various strengths for each active ingredient listed above.

Silvadene Cream - Side-effects

The following is a list of possible side-effects that may occur from all constituting ingredients of Silvadene Cream. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
  • Allergic
  • Silver building up in the body's tissue
  • Sulfonamide induced systemic toxicity
  • Interstitial inflammation of the kidneys
  • Rashes
  • Allergic reactions
  • Silvadene Cream may also cause side-effects not listed here.
If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
References: 2
Learn more: Side-effects

Silvadene Cream - Precautions & How to Use

Before using Silvadene Cream, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
  • Consult a doctor if you have renal or hepatic impairment
  • G6PD deficiency
  • do not take by mouth. Consult with your doctor before using this medicine on open wounds, dry, chapped, irritated, or sun-burned skin.
  • wash your hands before and after applying Silvadene Cream. Clean and dry the skin area to be treated.
  • do not wash the treated area after immediately applying Silvadene Cream. Also avoid the use of other products on the treated area unless directed by your doctor.
  • applying an excessive amount may result in pilling. Use a thinner layer or lesser quantity of medicine to avoid pilling.
  • avoid getting this medication in your eyes or nose or mouth.

Silvadene Cream - Drug Interactions

If you use other drugs or over the counter products at the same time, the effects of Silvadene Cream may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Silvadene Cream may interact with the following drugs and products:
Learn more: Interactions

Silvadene Cream - Contraindications

Hypersensitivity to Silvadene Cream is a contraindication. In addition, Silvadene Cream should not be used if you have the following conditions:
  • Acne
  • Hypersensitivity
  • Lactation
  • Neonates
  • Porphyria
  • Pregnancy
Learn more: Contraindications

Where to Buy Silvadene Cream

Click here to find nearby pharmacies/medical stores where you can buy Silvadene Cream.

Silvadene Cream - Frequently asked Questions

  • Is Silvadene Cream safe to consume or apply when pregnant?
  • Is Silvadene Cream safe while breastfeeding?
  • Can Silvadene Cream be used for burn infection and topical antimicrobial agent?
    Yes, burn infection and topical antimicrobial agent are among the most common reported uses for Silvadene Cream. Please do not use Silvadene Cream for burn infection and topical antimicrobial agent without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Silvadene Cream.
  • Should I consume Silvadene Cream empty stomach, before food or after food? website users have most commonly reported consuming Silvadene Cream after food. However, this may not be reflective of how you should consume this medicine. Please follow your doctor's advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Silvadene Cream.
  • Is it safe to drive or operate heavy machinery when consuming?
    If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Silvadene Cream medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Silvadene Cream. Always consult with your doctor for recommendations specific to your body and health conditions.
  • Is this medicine or product addictive or habit forming?
    Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
  • Can it be stopped immediately or do I have to slowly ween off consumption?
    Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

Other important Information on Silvadene Cream

Missing a dose

In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
References: 3, 4, 5, 6

Overdosage of Silvadene Cream

  • Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Silvadene Cream, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
  • Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
  • Please consult your physician or pharmacist or product package for more information.
References: 7, 8, 9

Storage of Silvadene Cream

  • Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
  • Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Silvadene Cream.
References: 10, 11, 12, 13

Expired Silvadene Cream

  • Taking a single dose of expired Silvadene Cream is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
References: 14, 15

Dosage Information

Please consult your physician or pharmacist or refer to product package.

Questions - Silvadene Cream

Silvadene is supplied as a cream and not as an ointment in the United States. Its generic name is silver sulfadiazine. It is indicated as an adjunct to the prevention and treatment of wound sepsis in patients with second- and third-degree burns. This medication has broad antimicrobial activity against gram-negative and gram-positive bacteria and yeast.

1. Silvadene. Package insert. URL: . Accessed 10/14/2017.
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News and Updates

Latest news and updates related to Silvadene Cream. Subscribe to get latest posts via email or subscribe to a RSS feed.

Tuesday, January 16, 2018 -- Pfizer subsidiary Greenstone has introduced its authorized generic of Silvadene Cream (silver sulfadiazine cream, 1%). Read More

Silvadene Cream - Packages and Strengths

Silvadene Cream is available in the following packages and strengths
Silvadene Cream - Packages: 1%

Silvadene Cream - Manufacturers

The medicine is manufactured by the following companies

Silvadene Cream - Demographic Information


  1. Dailymed LABEL: SILVER SULFADIAZINE - silver sulfadiazine cream - Accessed: October 12, 2016. (Accessed on 2/25/17)
  2. Dailymed LABEL: SILVER SULFADIAZINE - silver sulfadiazine cream - Accessed: October 12, 2016.
  3. - Accessed: July 14, 2016.
  4. - Accessed: July 3, 2016.
  5. Cancer.Net (2014). - Accessed: July 3, 2016.
  6. Schachter, S.C., Shafer, P. O. &; Sirven, J.I. (2013). - Accessed: May 28, 2016.
  7. National Institute of Drug Abuse (2010). - Accessed: July 21, 2016.
  8. eMedicinehealth (2016). - Accessed: July 21, 2016.
  9. Centers for Disease Control and Prevention (2010). - Accessed: July 21, 2016.
  10. Centers for Disease Control and Prevention. December 12, 2011. - Accessed: June 10, 2016.
  11. The Center for Improving Medication Management and the National Council on Patient Information and Education. - Accessed: June 10, 2016.
  12. U.S. Food and Drug Administration. December 24, 2013. - Accessed: June 10, 2016.
  13. World Health Organization: - Accessed: July 1, 2016.
  14. Lyon, R. C., Taylor, J. S., Porter, D. A., et al. (2006) Stability profiles of drug products extended beyond labeled expiration dates. Journal of Pharmaceutical Sciences; 95:1549-60 - Accessed: July 3, 2016.
  15. Harvard Medical School (2016). - Accessed: May 1, 2016.

Cite this page

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APA Style Citation

  • Silvadene Cream - Uses, Side-effects, Reviews, and Precautions - King Pharms - - USA. (n.d.). Retrieved January 21, 2018, from

MLA Style Citation

  • "Silvadene Cream - Uses, Side-effects, Reviews, and Precautions - King Pharms - - USA" N.p., n.d. Web. 21 Jan. 2018.

Chicago Style Citation

  • "Silvadene Cream - Uses, Side-effects, Reviews, and Precautions - King Pharms - - USA" Accessed January 21, 2018.

Last updated date

This page was last updated on 11/04/2017.
This page provides information for Silvadene Cream in English.
Read Reviews » Silvadene Cream

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