Epiduo Gel

    Uses, Side-effects, Reviews, and Precautions

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    What is Epiduo?

    Epiduo Gel is used for Acne, Mild to moderate acne, Keratosis pilaris and other conditions. Epiduo Gel may also be used for purposes not listed in this medication guide.
    Epiduo Gel contains Adapalene and Benzoyl Peroxide as active ingredients.
    Epiduo Gel works by inhibiting keratinocyte differentiation; attacking the bacteria which causes acne;
    Detailed information related to Epiduo Gel's uses, composition, dosage, side effects and reviews is listed below.

    Epiduo Gel Uses

    Epiduo Gel is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
    References: 1, 2, 3, 4
    Learn more: Uses

    Epiduo Gel Working, Mechanism of Action and Pharmacology

    Epiduo Gel improves the patient's condition by performing the following functions:
    References: 2, 5

    Epiduo Gel - Composition and Active Ingredients

    Epiduo Gel is composed of the following active ingredients (salts)
    Please note that this medicine may be available in various strengths for each active ingredient listed above.

    Epiduo Gel - Side-effects

    The following is a list of possible side-effects that may occur from all constituting ingredients of Epiduo Gel. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
    If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
    References: 6, 7
    Learn more: Side-effects

    Epiduo Gel - Precautions & How to Use

    Before using Epiduo Gel, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
    • Avoid contact with the eyes, lips, angles of the nose, and mucous membranes
    • Avoid products containing alpha hydroxyl or glycolic acids
    • Avoid wax epilation
    • Do not apply this gel on abrasions, cuts, eczematous or sunburned skin
    • For external use only
    • It is for external use only
    • do not take by mouth. Consult with your doctor before using this medicine on open wounds, dry, chapped, irritated, or sun-burned skin.
    • wash your hands before and after applying Epiduo Gel. Clean and dry the skin area to be treated.
    • do not wash the treated area after immediately applying Epiduo Gel. Also avoid the use of other products on the treated area unless directed by your doctor.
    • applying an excessive amount may result in pilling. Use a thinner layer or lesser quantity of medicine to avoid pilling.
    • avoid getting this medication in your eyes or nose or mouth.
    References: 8, 8, 10, 10

    Epiduo Gel - Drug Interactions

    If you use other drugs or over the counter products at the same time, the effects of Epiduo Gel may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Epiduo Gel may interact with the following drugs and products:
    • Alprazolam
    • Amphetamine
    • Aripiprazole
    • Ascorbic acid
    • Cetirizine
    • Cholecalciferol
    References: 8
    Learn more: Interactions

    Epiduo Gel - Contraindications

    Hypersensitivity to Epiduo Gel is a contraindication. In addition, Epiduo Gel should not be used if you have the following conditions:
    References: 8, 10
    Learn more: Contraindications

    Where to Buy Epiduo Gel

    Epiduo Gel - Frequently asked Questions

    • Is Epiduo Gel safe to consume or apply when pregnant?
      • Adapalene: No
      • Benzoyl Peroxide: Please consult with your doctor for case-specific recommendations.
      References: 8 10
    • Is Epiduo Gel safe while breastfeeding?
      • Adapalene: Please discuss the risks and benefits with your doctor.
      • Benzoyl Peroxide: Please discuss the risks and benefits with your doctor.
      References: 8 10
    • Can Epiduo Gel be used for acne and mild to moderate acne?
      Yes, acne and mild to moderate acne are among the most common reported uses for Epiduo Gel. Please do not use Epiduo Gel for acne and mild to moderate acne without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Epiduo Gel.
    • How long do I need to use Epiduo Gel before I see improvement of my conditions? website users have reported 2 weeks and > 3 months as the most common time it takes before they saw improvements in their conditions. These times may not be reflective of what you may experience or how you should use this medicine. Please consult with your doctor to check how long do you need to use Epiduo Gel. Click here and view survey results to find out what other patients report as time for effectiveness for Epiduo Gel.
    • Should I consume Epiduo Gel empty stomach, before food or after food? website users have most commonly reported consuming Epiduo Gel after food. However, this may not be reflective of how you should consume this medicine. Please follow your doctor's advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Epiduo Gel.
    • Is it safe to drive or operate heavy machinery when consuming?
      If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Epiduo Gel medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Epiduo Gel. Always consult with your doctor for recommendations specific to your body and health conditions.
    • Is this medicine or product addictive or habit forming?
      Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
    • Can it be stopped immediately or do I have to slowly ween off consumption?
      Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

    Other important Information on Epiduo Gel

    Missing a dose

    In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
    References: 12, 13, 14, 15

    Overdosage of Epiduo Gel

    • Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Epiduo Gel, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
    • Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
    • Please consult your physician or pharmacist or product package for more information.
    References: 16, 17, 18

    Storage of Epiduo Gel

    • Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
    • Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Epiduo Gel.
    References: 19, 20, 21, 22

    Expired Epiduo Gel

    • Taking a single dose of expired Epiduo Gel is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
    References: 23, 24

    Dosage Information

    Please consult your physician or pharmacist or refer to product package.

    Questions - Epiduo Gel

    No questions have been asked.

    News and Updates

    Latest news and updates related to Epiduo Gel. Subscribe to get latest posts via email or subscribe to a RSS feed.
    No posts found.

    Epiduo Gel - Packages and Strengths

    Epiduo Gel is available in the following packages and strengths
    Epiduo Gel - Packages: 30g Tube
    Epiduo Gel - Strengths: 0.1%+2.5%

    Epiduo Gel - Manufacturers

    The medicine is manufactured by the following companies

      Epiduo Gel - Demographic Information


      1. Rolewski S (2003). "Clinical review: topical retinoids". Dermatol Nurs. 15 (5): 447–50, 459–65. PMID 14619325. - Accessed: October 12, 2016.
      2. "FDA approves Differin Gel 0.1% for over-the-counter use to treat acne". July 8, 2016. Retrieved 23 August 2016. - Accessed: October 12, 2016.
      3. Simonart, T. (December 2012). "Newer approaches to the treatment of acne vulgaris". Am. J. Clin. Dermatol. 13 (6): 357–64. doi:10.2-000. PMID 22920095. - Accessed: October 12, 2016.
      4. Seidler, E. M.; Kimball, A. B. (July 2010). "Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne". J. Am. Acad. Dermatol. 63 (1): 52–62. doi:10.1016/j.jaad.2009.07.052. PMID 20488582. - Accessed: October 12, 2016.
      5. Fulton JE, Farzad-Bakshandeh A, Bradley S. Studies on the mechanism of action of topical benzoyl peroxide and vitamin A acid in acne vulgaris. Journal of Cutaneous Pathology. Volume 1, Issue 5 October 1974 191-200. DOI: 10.1111/j.1600-0560.1974tb00628.x
      6. PMC Ther Clin Risk Manag. 2007 Aug; 3(4): 621–624. Published online 2007 Aug. - Accessed: October 12, 2016.
      7. PubMed Health Benzoyl Peroxide (On the skin) - Accessed: October 12, 2016.
      8. DailyMed. Adapalene. Retrieved on 10/8/2016. - Accessed: October 12, 2016.
      9. DailyMed. Adapalene. Retrieved on 10/8/2016. - Accessed: October 12, 2016.
      10. Dailymed archived label: Perrigo Benzoyl Peroxide Wash. - Accessed: October 12, 2016.
      11. Dailymed archived label: Perrigo Benzoyl Peroxide Wash. - Accessed: October 12, 2016.
      12. - Accessed: July 14, 2016.
      13. - Accessed: July 3, 2016.
      14. Cancer.Net (2014). - Accessed: July 3, 2016.
      15. Schachter, S.C., Shafer, P. O. &; Sirven, J.I. (2013). - Accessed: May 28, 2016.
      16. National Institute of Drug Abuse (2010). - Accessed: July 21, 2016.
      17. eMedicinehealth (2016). - Accessed: July 21, 2016.
      18. Centers for Disease Control and Prevention (2010). - Accessed: July 21, 2016.
      19. Centers for Disease Control and Prevention. December 12, 2011. - Accessed: June 10, 2016.
      20. The Center for Improving Medication Management and the National Council on Patient Information and Education. - Accessed: June 10, 2016.
      21. U.S. Food and Drug Administration. December 24, 2013. - Accessed: June 10, 2016.
      22. World Health Organization: - Accessed: July 1, 2016.
      23. Lyon, R. C., Taylor, J. S., Porter, D. A., et al. (2006) Stability profiles of drug products extended beyond labeled expiration dates. Journal of Pharmaceutical Sciences; 95:1549-60 - Accessed: July 3, 2016.
      24. Harvard Medical School (2016). - Accessed: May 1, 2016.

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      • Epiduo Gel - Uses, Side-effects, Reviews, and Precautions - - UAE. (n.d.). Retrieved January 22, 2018, from

      MLA Style Citation

      • "Epiduo Gel - Uses, Side-effects, Reviews, and Precautions - - UAE" N.p., n.d. Web. 22 Jan. 2018.

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      • "Epiduo Gel - Uses, Side-effects, Reviews, and Precautions - - UAE" Accessed January 22, 2018.

      Last updated date

      This page was last updated on 1/14/2018.
      This page provides information for Epiduo Gel in English.
      Read Reviews » Epiduo Gel

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