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    What is Sinarest?

    Sinarest Tablet is used for Cold, Fever, Common cold, Catarrh, Nasal decongestant, Headache and other conditions. Sinarest Tablet may also be used for purposes not listed in this medication guide.
    Sinarest Tablet contains Chlorpheniramine, Paracetamol and Phenylephrine as active ingredients.
    Sinarest Tablet works by increasing the pain threshold and increases the blood flow across the skin, heat loss and sweating; constricting the blood vessels results in decreasing the flow of blood thus relieves nasal congestion; blocking H1-receptor sites on tissues;
    Centaur Pharma manufactures Sinarest Tablet.
    Detailed information related to Sinarest Tablet's uses, composition, dosage, side effects and reviews is listed below.

    Sinarest Tablet Uses

    Sinarest Tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
    References: 1, 2, 3
    Report:
    Learn more: Uses

    Sinarest Tablet Working, Mechanism of Action and Pharmacology

    Sinarest Tablet improves the patient's condition by performing the following functions:
    References: 4, 5, 6

    Sinarest Tablet - Composition and Active Ingredients

    Sinarest Tablet is composed of the following active ingredients (salts)
    Please note that this medicine may be available in various strengths for each active ingredient listed above.

    Sinarest Tablet - Side-effects

    The following is a list of possible side-effects that may occur from all constituting ingredients of Sinarest Tablet. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
    If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
    References: 4, 7, 8
    Report:
    Learn more: Side-effects

    Sinarest Tablet - Precautions & How to Use

    Before using Sinarest Tablet, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
    References: 9, 9

    Sinarest Tablet - Drug Interactions

    If you use other drugs or over the counter products at the same time, the effects of Sinarest Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Sinarest Tablet may interact with the following drugs and products:
    • Alcohol
    • Antipsychotics
    • Decongestants
    • Digoxin
    • High blood pressure medicines
    • Interfere with certain laboratory tests
    References: 9
    Learn more: Interactions

    Sinarest Tablet - Contraindications

    Hypersensitivity to Sinarest Tablet is a contraindication. In addition, Sinarest Tablet should not be used if you have the following conditions:
    Learn more: Contraindications

    Where to Buy Sinarest Tablet

    Click here to find nearby pharmacies/medical stores where you can buy Sinarest Tablet.

    Sinarest Tablet - Frequently asked Questions

    • Is Sinarest Tablet safe to consume or apply when pregnant?
      • Paracetamol: Please consult with your doctor for case-specific recommendations.
      • Phenylephrine: No
      • Chlorpheniramine: Please consult with your doctor for case-specific recommendations.
      References: 9
    • Is Sinarest Tablet safe while breastfeeding?
      • Paracetamol: Please discuss the risks and benefits with your doctor.
      • Phenylephrine: No
      • Chlorpheniramine: Please discuss the risks and benefits with your doctor.
      References: 9
    • Can Sinarest Tablet be used for cold and fever?
      Yes, cold and fever are among the most common reported uses for Sinarest Tablet. Please do not use Sinarest Tablet for cold and fever without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Sinarest Tablet.
    • How long do I need to use Sinarest Tablet before I see improvement of my conditions?
      all4insure.ru website users have reported 1 day and same day as the most common time it takes before they saw improvements in their conditions. These times may not be reflective of what you may experience or how you should use this medicine. Please consult with your doctor to check how long do you need to use Sinarest Tablet. Click here and view survey results to find out what other patients report as time for effectiveness for Sinarest Tablet.
    • At what frequency do I need to use Sinarest Tablet?
      all4insure.ru website users have reported twice a day and once a day as the most common frequency of using Sinarest Tablet. Please follow your doctor's advice on how often you need to Sinarest Tablet. Click here and view survey results to find out what other patients report as frequency of using Sinarest Tablet.
    • Should I consume Sinarest Tablet empty stomach, before food or after food?
      all4insure.ru website users have most commonly reported consuming Sinarest Tablet after food. However, this may not be reflective of how you should consume this medicine. Please follow your doctor's advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Sinarest Tablet.
    • Is it safe to drive or operate heavy machinery when consuming?
      If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Sinarest Tablet medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Sinarest Tablet. Always consult with your doctor for recommendations specific to your body and health conditions.
    • Is this medicine or product addictive or habit forming?
      Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
    • Can it be stopped immediately or do I have to slowly ween off consumption?
      Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

    Other important Information on Sinarest Tablet

    Missing a dose

    In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
    References: 11, 12, 13, 14

    Overdosage of Sinarest Tablet

    • Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Sinarest Tablet, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
    • Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
    • Please consult your physician or pharmacist or product package for more information.
    References: 15, 16, 17

    Storage of Sinarest Tablet

    • Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
    • Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Sinarest Tablet.
    References: 18, 19, 20, 21

    Expired Sinarest Tablet

    • Taking a single dose of expired Sinarest Tablet is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
    References: 22, 23

    Dosage Information

    Please consult your physician or pharmacist or refer to product package.

    Questions - Sinarest Tablet

    Sinarest should be banned because it contains multiple active ingredients which may cause serious side effects. Sinarest contains Paracetamol, Phenylephrine, Chlorpheniramine, and Caffeine as active ingredients. This combination drug can treat multiple symptoms of cold such as nasal congestion, pain, headache, and allergic symptoms of the nose or throat due to upper respiratory tract allergies. However, a patient may not have all these symptoms at the same time. Therefore, extra active ingredients may not be needed, but they are there to cause side effects.
    
    References
    1) Centaur Pharmaceuticals Sinarest tablet. Accessed January 1, 2018.
    2) Miracle drug’ for TB will be available in India soon. URL: . Accessed January 1, 2018.
    3) Top 10 commonly used medication now banned in India. URL: . Accessed January 1, 2018.
    Share
    Share the link to this answer
    Sinarest is recommended to be taken during pregnancy only under doctor's recommendation. It is an analgesic-antipyretic drug that contains Paracetamol, Phenylephrine and Chlorpheniramine maleate.
    
    US Food and Drug Administration (FDA) has specified Chlorphenamine maleate as a pregnancy category B drug which indicates that animal and human studies have failed to demonstrate a risk to the fetus in any trimester. A study published in 2008 in the Journal of Canadian Family Physician concluded that there was no increase in the risk of malformations when Chlorpheniramine maleate was used during pregnancy. However, another study published in 2013 showed that Chlorpheniramine was associated with eye and ear defects.
    
    Paracetamol has been specified as a pregnancy category C drug which indicates that animal studies show an adverse effect on the fetus but there are no teratogenic studies of Paracetamol in pregnant women. A study published in 2016 in the journal of clinical Psychiatry suggested that Paracetamol may be responsible for the increased risk of attention-deficit and hyperactivity disorder (ADHD) when used during pregnancy.
    
    Phenylephrine is the most commonly used oral decongestants in over the counter cold medications. In several studies, decongestant use in the first trimester is associated with a small arise of defects like vascular disruption, gastroschisis (a birth defect of the abdominal wall), small intestinal atresia (blockage in the small intestine), and hemifacial microsomia (a condition in which the lower half of one side of the face does not grow normally). However, there are various cohort and case-control studies that missed to show any enhanced risk of malformations with the use of oral decongestants during pregnancy. In addition, there was no prolonged risk of malformations in a current Swedish population-based case-control study including 2474 women exposed to oral decongestants throughout the first trimester and 1771 women exposed at the end of pregnancy.
    
    Women taking Sinarest are advised to notify their gynecologist if they become pregnant or intend to become pregnant during therapy.
    
    References
    1. Li Q, Mitchell AA, Werler MM, Yau WP, Hernández-díaz S. Assessment of antihistamine use in early pregnancy and birth defects. J Allergy Clin Immunol Pract. 2013;1(6):666-74.e1 URL: Accessed December 27, 2017
    2. Gilboa SM, Strickland MJ, Olshan AF, Werler MM, Correa A. Use of antihistamine medications during early pregnancy and isolated major malformations. Birth Defects Res Part A Clin Mol Teratol. 2009;85(2):137-50 URL: Accessed December 27, 2017
    3. Wikipedia Paracetamol URL: Accessed December 27, 2017
    4. Andrade C. Use of acetaminophen (paracetamol) during pregnancy and the risk of attention-deficit/hyperactivity disorder in the offspring. J Clin Psychiatry. 2016;77(3):e312-4 URL: Accessed December 27, 2017
    5. MedlinePlus Phenylephrine URL:/ Accessed December 27, 2017
    6. Erebara A, Bozzo P, Einarson A, Koren G. Treating the common cold during pregnancy. Canadian Family Physician. 2008;54(5):687-689. URL: Accessed December 27, 2017
    7. CentaurPharma Sinarest Tablet URL: Accessed December 27, 2017
    Share
    Share the link to this answer
    Sinarest is recommended to be taken during pregnancy only under doctor's recommendation. It is an analgesic-antipyretic drug that contains Paracetamol, Phenylephrine and Chlorpheniramine maleate.
    
    US Food and Drug Administration (FDA) has specified Chlorphenamine maleate as a pregnancy category B drug which indicates that animal and human studies have failed to demonstrate a risk to the fetus in any trimester. A study published in 2008 in the Journal of Canadian Family Physician concluded that there was no increase in the risk of malformations when Chlorpheniramine maleate was used during pregnancy. However, another study published in 2013 showed that Chlorpheniramine was associated with eye and ear defects.
    
    Paracetamol has been specified as a pregnancy category C drug which indicates that animal studies show an adverse effect on the fetus but there are no teratogenic studies of Paracetamol in pregnant women. A study published in 2016 in the journal of clinical Psychiatry suggested that Paracetamol may be responsible for the increased risk of attention-deficit and hyperactivity disorder (ADHD) when used during pregnancy.
    
    Phenylephrine is the most commonly used oral decongestants in over the counter cold medications. In several studies, decongestant use in the first trimester is associated with a small arise of defects like vascular disruption, gastroschisis (a birth defect of the abdominal wall), small intestinal atresia (blockage in the small intestine), and hemifacial microsomia (a condition in which the lower half of one side of the face does not grow normally). However, there are various cohort and case-control studies that missed to show any enhanced risk of malformations with the use of oral decongestants during pregnancy. In addition, there was no prolonged risk of malformations in a current Swedish population-based case-control study including 2474 women exposed to oral decongestants throughout the first trimester and 1771 women exposed at the end of pregnancy.
    
    Women taking Sinarest are advised to notify their gynecologist if they become pregnant or intend to become pregnant during therapy.
    
    References
    1. Li Q, Mitchell AA, Werler MM, Yau WP, Hernández-díaz S. Assessment of antihistamine use in early pregnancy and birth defects. J Allergy Clin Immunol Pract. 2013;1(6):666-74.e1 URL: Accessed December 27, 2017
    2. Gilboa SM, Strickland MJ, Olshan AF, Werler MM, Correa A. Use of antihistamine medications during early pregnancy and isolated major malformations. Birth Defects Res Part A Clin Mol Teratol. 2009;85(2):137-50 URL: Accessed December 27, 2017
    3. Wikipedia Paracetamol URL: Accessed December 27, 2017
    4. Andrade C. Use of acetaminophen (paracetamol) during pregnancy and the risk of attention-deficit/hyperactivity disorder in the offspring. J Clin Psychiatry. 2016;77(3):e312-4 URL: Accessed December 27, 2017
    5. MedlinePlus Phenylephrine URL:/ Accessed December 27, 2017
    6. Erebara A, Bozzo P, Einarson A, Koren G. Treating the common cold during pregnancy. Canadian Family Physician. 2008;54(5):687-689. URL: Accessed December 27, 2017
    7. CentaurPharma Sinarest Tablet URL: Accessed December 27, 2017
    Share
    Share the link to this answer
    Sinarest is recommended to be taken during pregnancy only under doctor's recommendation. It is an analgesic-antipyretic drug that contains Paracetamol, Phenylephrine and Chlorpheniramine maleate.
    
    US Food and Drug Administration (FDA) has specified Chlorphenamine maleate as a pregnancy category B drug which indicates that animal and human studies have failed to demonstrate a risk to the fetus in any trimester. A study published in 2008 in the Journal of Canadian Family Physician concluded that there was no increase in the risk of malformations when Chlorpheniramine maleate was used during pregnancy. However, another study published in 2013 showed that Chlorpheniramine was associated with eye and ear defects.
    
    Paracetamol has been specified as a pregnancy category C drug which indicates that animal studies show an adverse effect on the fetus but there are no teratogenic studies of Paracetamol in pregnant women. A study published in 2016 in the journal of clinical Psychiatry suggested that Paracetamol may be responsible for the increased risk of attention-deficit and hyperactivity disorder (ADHD) when used during pregnancy.
    
    Phenylephrine is the most commonly used oral decongestants in over the counter cold medications. In several studies, decongestant use in the first trimester is associated with a small arise of defects like vascular disruption, gastroschisis (a birth defect of the abdominal wall), small intestinal atresia (blockage in the small intestine), and hemifacial microsomia (a condition in which the lower half of one side of the face does not grow normally). However, there are various cohort and case-control studies that missed to show any enhanced risk of malformations with the use of oral decongestants during pregnancy. In addition, there was no prolonged risk of malformations in a current Swedish population-based case-control study including 2474 women exposed to oral decongestants throughout the first trimester and 1771 women exposed at the end of pregnancy.
    
    Women taking Sinarest are advised to notify their gynecologist if they become pregnant or intend to become pregnant during therapy.
    
    References
    1. Li Q, Mitchell AA, Werler MM, Yau WP, Hernández-díaz S. Assessment of antihistamine use in early pregnancy and birth defects. J Allergy Clin Immunol Pract. 2013;1(6):666-74.e1 URL: Accessed December 27, 2017
    2. Gilboa SM, Strickland MJ, Olshan AF, Werler MM, Correa A. Use of antihistamine medications during early pregnancy and isolated major malformations. Birth Defects Res Part A Clin Mol Teratol. 2009;85(2):137-50 URL: Accessed December 27, 2017
    3. Wikipedia Paracetamol URL: Accessed December 27, 2017
    4. Andrade C. Use of acetaminophen (paracetamol) during pregnancy and the risk of attention-deficit/hyperactivity disorder in the offspring. J Clin Psychiatry. 2016;77(3):e312-4 URL: Accessed December 27, 2017
    5. MedlinePlus Phenylephrine URL:/ Accessed December 27, 2017
    6. Erebara A, Bozzo P, Einarson A, Koren G. Treating the common cold during pregnancy. Canadian Family Physician. 2008;54(5):687-689. URL: Accessed December 27, 2017
    7. CentaurPharma Sinarest Tablet URL: Accessed December 27, 2017
    Share
    Share the link to this answer
    Sinarest Tablet contains a clinically proven analgesic-antipyretic Paracetamol with decongestant Phenylephrine and an antihistamine Chlorpheniramine maleate (Centaur Pharmaceuticals, n.d.). Paracetamol produces analgesia by elevation of the pain threshold by acting on the hypothalamic heat-regulating center. It is recemmended to counsel with the health care provider before taking Sinarest if breastfeeding.
    
    References
    1. Centaur Pharmaceuticals (n.d.) website. Sinarest Tablet.
    Share
    Share the link to this answer

    News and Updates

    Latest news and updates related to Sinarest Tablet. Subscribe to get latest posts via email or subscribe to a RSS feed.
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    Sinarest Tablet - Packages and Strengths

    Sinarest Tablet is available in the following packages and strengths
    Sinarest Tablet - Packages: 10 Tablet, 15ML Drops
    Sinarest Tablet - Strengths: 500MG+10MG+2MG

    Sinarest Tablet - Manufacturers

    The medicine is manufactured by the following companies

    Sinarest Tablet - Demographic Information

    References

    1. DailyMed LABEL: ACETAMINOPHEN - acetaminophen tablet, coated - Accessed: October 12, 2016.
    2. Source: MeSH Record Name: Phenylephrine - Accessed: October 12, 2016.
    3. Postgrad Med J. 1982 Jul; 58(681): 422–423. PMCID: PMC2426514 Controlled trial of terfenadine and chlorpheniramine maleate in perennial rhinitis - Accessed: October 12, 2016.
    4. Pubchem Acetaminophen - Accessed: October 12, 2016.
    5. Source: NCIt Record Name: Phenylephrine Base - Accessed: October 12, 2016.
    6. Carlsson, A.; Linqvist M. (1969). "Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines". Journal of Pharmacy and Pharmacology. 21 (7): 460–464. doi:10.1111/j.2042-7158.1969.tb08287.x. PMID 4390069. - Accessed: October 12, 2016.
    7. - Accessed: October 12, 2016.
    8. Hasenöhrl, R. U.; Weth, K.; Huston, J. P. (1999). "Intraventricular infusion of the histamine H1 receptor antagonist chlorpheniramine improves maze performance and has anxiolytic-like effects in aged hybrid Fischer 344×Brown Norway rats". Experimental Brain Research. 128 (4): 435–440. doi:10.1007/s. PMID 10541737. - Accessed: October 12, 2016.
    9. Dailymed label: CHLORPHENIRAMINE MALEATE- chlorpheniramine maleate tablet. - Accessed: October 12, 2016.
    10. Dailymed label: CHLORPHENIRAMINE MALEATE- chlorpheniramine maleate tablet. - Accessed: October 12, 2016.
    11. - Accessed: July 14, 2016.
    12. - Accessed: July 3, 2016.
    13. Cancer.Net (2014). - Accessed: July 3, 2016.
    14. Schachter, S.C., Shafer, P. O. &; Sirven, J.I. (2013). - Accessed: May 28, 2016.
    15. National Institute of Drug Abuse (2010). - Accessed: July 21, 2016.
    16. eMedicinehealth (2016). - Accessed: July 21, 2016.
    17. Centers for Disease Control and Prevention (2010). - Accessed: July 21, 2016.
    18. Centers for Disease Control and Prevention. December 12, 2011. - Accessed: June 10, 2016.
    19. The Center for Improving Medication Management and the National Council on Patient Information and Education. - Accessed: June 10, 2016.
    20. U.S. Food and Drug Administration. December 24, 2013. - Accessed: June 10, 2016.
    21. World Health Organization: - Accessed: July 1, 2016.
    22. Lyon, R. C., Taylor, J. S., Porter, D. A., et al. (2006) Stability profiles of drug products extended beyond labeled expiration dates. Journal of Pharmaceutical Sciences; 95:1549-60 - Accessed: July 3, 2016.
    23. Harvard Medical School (2016). - Accessed: May 1, 2016.

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    Last updated date

    This page was last updated on 1/22/2018.
    This page provides information for Sinarest Tablet in English.
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