Friday, January 19, 2018 -- According to long-term follow-up results from the National Surgical Adjuvant Breast and Bowel Project B-31 trial published in the Journal of Clinical Oncology, trastuzumab (Herceptin) did not reduce cardiac function in women with node-positive, HER2+, early-stage breast cancer.
Friday, January 19, 2018 -- MedicalResearch.com Interview with: Prof. Dr. Dirk Bassler, MSc Head of Department, Professor of Neonatology Department of Neonatology University Hospital Zurich and University of Zurich Zurich, Switzerland MedicalResearch.com: What is the background for this study? Response: Bronchopulmonary dysplasia (BPD), a form … Continue reading →
Thursday, January 18, 2018 -- Z-CAN was designed as a short-term response for rapid implementation of reversible contraceptive services in a complex emergency setting in Puerto Rico and has served more than 21 000 women. This model could be replicated or adapted as part of future emergency preparedness and response efforts.
Thursday, January 18, 2018 -- by Todd M. Pollack, Hao T. Duong, Phuong T. Truong, Thuy T. Pham, Cuong D. Do, Donn Colby The use of dried blood spot (DBS) specimens for HIV viral load (VL) monitoring is recommended to support the roll-out of routine VL monitoring in low and middle income countries (LMICs). To better understand the use of DBS for VL monitoring, we evaluated two DBS testing methods, Roche TaqMan® Free Virus Evolution protocol (DBS-FVE) and Roche TaqMan® SPEX protocol (DBS-SPEX)) in patients receiving ART at an HIV clinic in Hanoi, Vietnam. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for each DBS testing method at the thresholds of 1000 and 5000 copies/ml compared to plasma VL.
Thursday, January 18, 2018 -- by Jyotsna Sridharan, Tomomi Haremaki, Daniel C. Weinstein Apolipoprotein CI (ApoCI) belongs to the Apolipoprotein superfamily, members of which are involved in lipid transport, uptake and homeostasis. Excessive ApoCI has been implicated in atherosclerosis and Alzheimer’s disease in humans. In this study we report the isolation of Xenopus laevis apoCI and describe the expression pattern of this gene during early development, using reverse transcription polymerase chain reaction and whole mount in situ hybridization. Xenopus apoCI is enriched in the dorsal ectoderm during gastrulation, and is subsequently expressed in sensory placodes, neural tube and cranial neural crest. These data suggest as yet uncharacterized roles for ApoCI during early vertebrate embryogenesis.
Thursday, January 18, 2018 -- by Lars Mundhenk, Nancy A. Erickson, Nikolai Klymiuk, Achim D. Gruber Members of the chloride channel regulators, calcium-activated (CLCA) family, have been implicated in diverse biomedical conditions, including chronic inflammatory airway diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis, the activation of macrophages, and the growth and metastatic spread of tumor cells. Several observations, however, could not be repeated across species boundaries and increasing evidence suggests that select CLCA genes are particularly prone to dynamic species-specific evolvements. Here, we systematically characterized structural and expressional differences of the CLCA3 gene across mammalian species, revealing a spectrum of gene duplications, e.g., in mice and cows, and of gene silencing via diverse chromosomal modifications in pigs and many primates,
Thursday, January 18, 2018 -- by Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama The potential effects of adipose tissue-derived mesenchymal stem cells (AT-MSCs) on the growth and invasion of canine tumours including hepatocellular carcinoma (HCC) are not yet understood. Moreover in humans, the functional contribution of AT-MSCs to malignancies remains controversial. The purpose of this study was to investigate the effects of AT-MSCs on the proliferation and invasion of canine HCC cells in vitro. The effect of AT-MSCs on mRNA levels of factors related to HCC progression were also evaluated. Conditioned medium from AT-MSCs (AT-MSC-CM) significantly enhanced canine HCC cell proliferation and invasion. Moreover, mRNA expression levels of transforming growth factor-beta 1, epidermal growth factor A, hepatocyte growth factor, platelet-derived growth factor-beta, vascular endothelial growth
Thursday, January 18, 2018 -- (Natural News) Combining carnitine with vitamin E may effectively reduce the risk of developing myocardial infarction (MI), according to a study published in the African Journal of Traditional Complementary and Alternative Medicines. A team of health experts at the King Abdulaziz University in Saudi Arabia used animal models of MI to carry out the study. The rats were divided into... Read More
Thursday, January 18, 2018 -- IRVING, Texas, Jan. 18, 2018 -- Reata Pharmaceuticals, Inc. (Nasdaq:RETA) (“Reata” or “the Company”), a clinical-stage biopharmaceutical company, today announced the digital publication of an original research article,...
Thursday, January 18, 2018 -- In this multicenter study, investigators evaluated the performance and safety of the Xen 45 ab interno gelatin stent (Allergan) for refractory glaucoma through a 12-month follow-up period.
Thursday, January 18, 2018 -- Researchers have found that the anti-anginal drug called ranolazine may help those not only with angina but type 2 diabetes, as well. Angina is very common in the United States. It is chest pain having to do with the heart and is an early warning sign of heart disease. The researchers reviewed reports that mentioned […]
Thursday, January 18, 2018 -- Investigators from Massachusetts General Hospital (MGH) have made some interesting findings about methicillin-resistant Staphylococcus aureu (MRSA) that may hold the key to curbing lymphatic repercussions.
Thursday, January 18, 2018 -- Data presented at the 2018 Gastrointestinal Cancers Symposium compared overall survival with cytoreductive surgery (CRS) alone for patients with gastric cancer and peritoneal carcinomatosis vs treatment with HIPEC plus CRS.
Thursday, January 18, 2018 -- Kite, a Gilead Company, and Pfizer said today they will assess a combination therapy for refractory large B-cell lymphoma that combines Kite’s approved chimeric antigen receptor T-cell (CAR-T) treatment Yescarta™ (axicabtagene ciloleucel) with Pfizer’s Phase I immunotherapy candidate utomilumab (PF-05082566). The companies said a multi-center Phase I/II study to be sponsored by Kite is expected to launch in 2018. The study’s results will be used to evaluate options for further development of the combination, or similar combinations between Kite’s engineered T cell products and utomilumab, a fully humanized 4-1BB agonist monoclonal antibody. Yescarta was approved in October as the second CAR-T therpay to win FDA authorization, and the first indicated for adults with relapsed or refractory large B-cell lymphoma
Thursday, January 18, 2018 -- Diets high in foods with potential to cause inflammation—including processed meat, red meat, fish and refined grains—are associated with an increased risk of developing colorectal cancer, according to a new study published in JAMA Oncology.
Thursday, January 18, 2018 -- A thorough review has evaluated whether a vitamin D supplement can help prevent non-skeletal disorders, including cardiovascular diseases and mood disorders. Vitamin D and its most important forms, vitamin D2 (ergocalciferol) and D3 (cholecalciferol) are essential for the absorption of calcium, magnesium and phosphate in the intestine. Most of the vitamin D required for humans comes from chemical […] The post Can a Vitamin D Supplement Improve Non-Skeletal Disorders? appeared first on Medical News Bulletin | Health News and Medical Research.
Thursday, January 18, 2018 -- Chemotherapy-free, immunotherapeutic combination evaluated32% Overall response rate in second-line gastric cancer patientsWell tolerated in dose escalation and expansion cohorts Rockville, MD, Jan. 18, 2018 -- ...
Thursday, January 18, 2018 -- Use of a non-sterile injectable product could result in fatal infections.
Thursday, January 18, 2018 -- ADHD medication prescriptions are increasingly common among privately insured, reproductive-aged women.
Thursday, January 18, 2018 -- (MedPage Today) -- Meta-analysis compares three classes of treatment head to head