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What is Isotretinoin?

Isotretinoin is used for Severe skin problems and other conditions. This salt may also be used for purposes not listed in this medication guide. Detailed information related to Isotretinoin's uses, side-effects, reviews, questions, interactions, and precautions is as follows:

Isotretinoin Uses

Isotretinoin is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
  • Severe skin problems
  • Isotretinoin may also be used for purposes not listed here.
References: 1
Learn more: Uses

Isotretinoin Working, Mechanism of Action and Pharmacology

Isotretinoin improves the patient's condition by performing the following functions:
References: 1

Isotretinoin - Side-effects

The following is a list of possible side-effects that may occur in medicines that contain Isotretinoin. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
References: 1
Learn more: Side-effects

Isotretinoin - Precautions & How to Use

Before using Isotretinoin, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
  • Avoid blood donation till 30 days after treatment
  • Men must use contraception
  • Monitor blood lipid levels, liver function, blood cell count and pregnancy test before treatment
  • Planning to get pregnant
  • Use sunscreen
  • Women must use at least two methods of contraception

Isotretinoin - Drug Interactions

If you use other drugs or over the counter products at the same time, the effects of Isotretinoin may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Isotretinoin may interact with the following drugs and products:
Learn more: Interactions

Isotretinoin - Contraindications

Hypersensitivity to Isotretinoin is a contraindication. In addition, Isotretinoin should not be used if you have the following conditions:
  • Allergic reactions
  • Breastfeeding
  • Laser skin treatments
  • Pregnant
  • Vitamin A supplements
  • Waxing for hair removal
Learn more: Contraindications

Where to Buy Isotretinoin

Click here to find nearby pharmacies/medical stores where you can buy Isotretinoin.

Isotretinoin - Frequently asked Questions

  • Is Isotretinoin safe to consume or apply when pregnant?
  • Is Isotretinoin safe while breastfeeding?
  • How long do I need to use Isotretinoin before I see improvement of my conditions? website users have reported 1 month and same day as the most common time it takes before they saw improvements in their conditions. These times may not be reflective of what you may experience or how you should use this medicine. Please consult with your doctor to check how long do you need to use Isotretinoin. Click here to find out what other patients report as time for effectiveness for Isotretinoin.
  • At what frequency do I need to use Isotretinoin? website users have reported once a day and twice a day as the most common frequency of using Isotretinoin. Please follow your doctor's advice on how often you need to Isotretinoin. Click here to find out what other patients report as frequency of using Isotretinoin.
  • Should I consume Isotretinoin empty stomach, before food or after food? website users have most commonly reported consuming Isotretinoin after food. However, this may not be reflective of how you should consume this medicine. Please follow your doctor's advice on how you should use this medicine. Click here to find out what other patients report as timing of using Isotretinoin.
  • Is it safe to drive or operate heavy machinery when consuming?
    If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Isotretinoin medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Isotretinoin. Always consult with your doctor for recommendations specific to your body and health conditions.
  • Is this medicine or product addictive or habit forming?
    Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
  • Can it be stopped immediately or do I have to slowly ween off consumption?
    Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

Other important Information on Isotretinoin

Missing a dose

In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
References: 2, 3, 4, 5

Overdosage of Isotretinoin

  • Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Isotretinoin, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
  • Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
  • Please consult your physician or pharmacist or product package for more information.
References: 6, 7, 8

Storage of Isotretinoin

  • Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
  • Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Isotretinoin.
References: 9, 10, 11, 12

Expired Isotretinoin

  • Taking a single dose of expired Isotretinoin is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
References: 13, 14

Dosage Information

Please consult your physician or pharmacist or refer to product package.

Questions - Isotretinoin

News and Updates

Latest news and updates related to Isotretinoin. Subscribe to get latest posts via email or subscribe to a RSS feed.

Monday, October 02, 2017 -- Isotretinoin is the most effective acne therapy available, but has the potential for a number of adverse side effects, including transaminitis. The iPLEDGE isotretinoin program recommends avoiding some herbals and supplements due to potential side effects. However, little is known about the effects of protein supplements on the liver, particularly in patients taking isotretinoin. We designed a retrospective chart review to evaluate the symptoms, diagnosis, treatment, and outcome of patients on or preparing to take isotretinoin therapy who were concurrently ingesting protein or herbal supplementation and who developed transaminitis. In 100% (8/8) of cases, dietary supplementation was determined to be at least a possible cause of elevated liver transaminases. In 75% (6/8) of cases, dietary supplement appears to be

Friday, September 22, 2017 -- Oral treatment shows better, earlier response than topical isotretinoin

Thursday, June 29, 2017 -- Mechanical dermabrasion and fully ablative laser not recommended in setting of systemic treatment

Thursday, June 22, 2017 -- Case report describes 19-year-old woman who had unsatisfactory aesthetic result from tattooing

Isotretinoin - Demographic Information


  1. Dailymed LABEL: ABSORICA- isotretinoin capsule - Accessed: October 12, 2016.
  2. - Accessed: July 14, 2016.
  3. - Accessed: July 3, 2016.
  4. Cancer.Net (2014). - Accessed: July 3, 2016.
  5. Schachter, S.C., Shafer, P. O. &; Sirven, J.I. (2013). - Accessed: May 28, 2016.
  6. National Institute of Drug Abuse (2010). - Accessed: July 21, 2016.
  7. eMedicinehealth (2016). - Accessed: July 21, 2016.
  8. Centers for Disease Control and Prevention (2010). - Accessed: July 21, 2016.
  9. Centers for Disease Control and Prevention. December 12, 2011. - Accessed: June 10, 2016.
  10. The Center for Improving Medication Management and the National Council on Patient Information and Education. - Accessed: June 10, 2016.
  11. U.S. Food and Drug Administration. December 24, 2013. - Accessed: June 10, 2016.
  12. World Health Organization: - Accessed: July 1, 2016.
  13. Lyon, R. C., Taylor, J. S., Porter, D. A., et al. (2006) Stability profiles of drug products extended beyond labeled expiration dates. Journal of Pharmaceutical Sciences; 95:1549-60 - Accessed: July 3, 2016.
  14. Harvard Medical School (2016). - Accessed: May 1, 2016.

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APA Style Citation

  • Isotretinoin - Uses, Side-effects, Reviews, and Precautions - (n.d.). Retrieved January 16, 2018, from

MLA Style Citation

  • "Isotretinoin - Uses, Side-effects, Reviews, and Precautions -" N.p., n.d. Web. 16 Jan. 2018.

Chicago Style Citation

  • "Isotretinoin - Uses, Side-effects, Reviews, and Precautions -" Accessed January 16, 2018.

Last updated date

This page was last updated on 1/11/2018.
This page provides information for Isotretinoin in English.
Read Reviews » Isotretinoin

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