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What is Hyaluronidase?

Hyaluronidase is used for Injection sites, Diffusion of fluids at subcutaneous route and other conditions. This salt may also be used for purposes not listed in this medication guide. Detailed information related to Hyaluronidase's uses, side-effects, reviews, questions, interactions, and precautions is as follows:

Hyaluronidase Uses

Hyaluronidase is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
  • Injection sites
  • Diffusion of fluids at subcutaneous route
  • Hyaluronidase may also be used for purposes not listed here.
References: 1
Learn more: Uses

Hyaluronidase Working, Mechanism of Action and Pharmacology

Hyaluronidase improves the patient's condition by performing the following functions:
References: 1

Hyaluronidase - Side-effects

The following is a list of possible side-effects that may occur in medicines that contain Hyaluronidase. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
References: 1
Learn more: Side-effects

Hyaluronidase - Precautions & How to Use

Before using Hyaluronidase, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

Hyaluronidase - Drug Interactions

If you use other drugs or over the counter products at the same time, the effects of Hyaluronidase may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Hyaluronidase may interact with the following drugs and products:
Learn more: Interactions

Hyaluronidase - Contraindications

Hypersensitivity to Hyaluronidase is a contraindication. In addition, Hyaluronidase should not be used if you have the following conditions:
  • Cancer
  • Direct application in eye
  • Hypersensitivity
Learn more: Contraindications

Where to Buy Hyaluronidase

Click here to find nearby pharmacies/medical stores where you can buy Hyaluronidase.

Hyaluronidase - Frequently asked Questions

  • Is Hyaluronidase safe to consume or apply when pregnant?
    Please consult with your doctor for case-specific recommendations.
  • Is Hyaluronidase safe while breastfeeding?
    Please discuss the risks and benefits with your doctor.
  • Can Hyaluronidase be used for injection sites and diffusion of fluids at subcutaneous route?
    Yes, injection sites and diffusion of fluids at subcutaneous route are among the most common reported uses for Hyaluronidase. Please do not use Hyaluronidase for injection sites and diffusion of fluids at subcutaneous route without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Hyaluronidase.
  • Is it safe to drive or operate heavy machinery when consuming?
    If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Hyaluronidase medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Hyaluronidase. Always consult with your doctor for recommendations specific to your body and health conditions.
  • Is this medicine or product addictive or habit forming?
    Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
  • Can it be stopped immediately or do I have to slowly ween off consumption?
    Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

Other important Information on Hyaluronidase

Missing a dose

In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
References: 2, 3, 4, 5

Overdosage of Hyaluronidase

  • Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Hyaluronidase, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
  • Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
  • Please consult your physician or pharmacist or product package for more information.
References: 6, 7, 8

Storage of Hyaluronidase

  • Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
  • Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Hyaluronidase.
References: 9, 10, 11, 12

Expired Hyaluronidase

  • Taking a single dose of expired Hyaluronidase is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
References: 13, 14

Dosage Information

Please consult your physician or pharmacist or refer to product package.

Questions - Hyaluronidase

News and Updates

Latest news and updates related to Hyaluronidase. Subscribe to get latest posts via email or subscribe to a RSS feed.

Tuesday, November 21, 2017 -- The cell surface protein CD44 is involved in diverse physiological processes, and its aberrant function is linked to various pathologies such as cancer, immune dysregulation, and fibrosis. The diversity of CD44 biological activity is partly conferred by the generation of distinct CD44 isoforms through alternative splicing. We identified an unexpected function for the ubiquitous hyaluronan-degrading enzyme, hyaluronidase 2 (HYAL2), as a regulator of CD44 splicing. Standard CD44 is associated with fibrotic disease, and its production is promoted through serine-arginine–rich (SR) protein–mediated exon exclusion. HYAL2 nuclear translocation was stimulated by bone morphogenetic protein 7, which inhibits the myofibroblast phenotype. Nuclear HYAL2 displaced SR proteins from the spliceosome, thus enabling HYAL2, spliceosome components (U1 and U2 small nuclear ribonucleoproteins), and CD44

Friday, June 23, 2017 -- The FDA granted approval to rituximab and hyaluronidase human as a subcutaneous injection for the treatment of follicular lymphoma, chronic lymphocytic leukemia, and DLBCL.

Thursday, June 08, 2017 -- Lower concentrations of hyaluronidase were as effective as higher concentrations at degrading hyaluronic acid fillers, according to study results published in Dermatologic Surgery.Margit L. W. Juhász, MD, of the dermatology department, Icahn School of Medicine at Mount Sinai, New York, and colleagues conducted a blinded randomized study of 15 volunteers (mean age, 27.2 years; 53.3% women). Hyaluronic acid (HA)-based reversible fillers, including Boletero Balance (Merz Aesthetics), Juvéderm Ultra XC, Juvéderm Ultra Plus, Juvéderm Voluma XC (all, Allergan), Resytlane-L, Restylane Silk and Perlane/Restylane Lyft (all, Galderma) were injected into the patients’ back, each 3 cm apart.

Hyaluronidase - Demographic Information


  1. DailyMed LABEL: HYLENEX RECOMBINANT- hyaluronidase recombinant human injection, solution - Accessed: October 12, 2016.
  2. - Accessed: July 14, 2016.
  3. - Accessed: July 3, 2016.
  4. Cancer.Net (2014). - Accessed: July 3, 2016.
  5. Schachter, S.C., Shafer, P. O. &; Sirven, J.I. (2013). - Accessed: May 28, 2016.
  6. National Institute of Drug Abuse (2010). - Accessed: July 21, 2016.
  7. eMedicinehealth (2016). - Accessed: July 21, 2016.
  8. Centers for Disease Control and Prevention (2010). - Accessed: July 21, 2016.
  9. Centers for Disease Control and Prevention. December 12, 2011. - Accessed: June 10, 2016.
  10. The Center for Improving Medication Management and the National Council on Patient Information and Education. - Accessed: June 10, 2016.
  11. U.S. Food and Drug Administration. December 24, 2013. - Accessed: June 10, 2016.
  12. World Health Organization: - Accessed: July 1, 2016.
  13. Lyon, R. C., Taylor, J. S., Porter, D. A., et al. (2006) Stability profiles of drug products extended beyond labeled expiration dates. Journal of Pharmaceutical Sciences; 95:1549-60 - Accessed: July 3, 2016.
  14. Harvard Medical School (2016). - Accessed: May 1, 2016.

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APA Style Citation

  • Hyaluronidase - Uses, Side-effects, Reviews, and Precautions - (n.d.). Retrieved January 20, 2018, from

MLA Style Citation

  • "Hyaluronidase - Uses, Side-effects, Reviews, and Precautions -" N.p., n.d. Web. 20 Jan. 2018.

Chicago Style Citation

  • "Hyaluronidase - Uses, Side-effects, Reviews, and Precautions -" Accessed January 20, 2018.

Last updated date

This page was last updated on 1/06/2018.
This page provides information for Hyaluronidase in English.
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