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    What is Divalproex Sodium?

    Divalproex Sodium is used for Manic phase of bipolar disorder, Migraine headache, Seizure disorder, Seizure disorders and other conditions. This salt may also be used for purposes not listed in this medication guide. Detailed information related to Divalproex Sodium's uses, side-effects, reviews, questions, interactions, and precautions is as follows:

    Divalproex Sodium Uses

    Divalproex Sodium is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
    Learn more: Uses

    Divalproex Sodium Working, Mechanism of Action and Pharmacology

    Divalproex Sodium improves the patient's condition by performing the following functions:

    Divalproex Sodium - Side-effects

    The following is a list of possible side-effects that may occur in medicines that contain Divalproex Sodium. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
    If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
    Learn more: Side-effects

    Divalproex Sodium - Precautions & How to Use

    Before using Divalproex Sodium, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

    Divalproex Sodium - Drug Interactions

    If you use other drugs or over the counter products at the same time, the effects of Divalproex Sodium may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Divalproex Sodium may interact with the following drugs and products:
    • Aripiprazole
    • Clonazepam
    • Duloxetine
    • Escitalopram
    • Lamotrigine
    • Lorazepam
    Learn more: Interactions

    Divalproex Sodium - Contraindications

    Hypersensitivity to Divalproex Sodium is a contraindication. In addition, Divalproex Sodium should not be used if you have the following conditions:
    • Breastfeeding
    • Family history of urea cycle disorder or unexplained infant deaths
    • History of mental or mood problems
    • Hypersensitivity
    • Pregnancy
    Learn more: Contraindications

    Where to Buy Divalproex Sodium

    Click here to find nearby pharmacies/medical stores where you can buy Divalproex Sodium.

    Divalproex Sodium - Frequently asked Questions

    • Is Divalproex Sodium safe to consume or apply when pregnant?
    • Is Divalproex Sodium safe while breastfeeding?
    • Can Divalproex Sodium be used for manic phase of bipolar disorder and migraine headache?
      Yes, manic phase of bipolar disorder and migraine headache are among the most common reported uses for Divalproex Sodium. Please do not use Divalproex Sodium for manic phase of bipolar disorder and migraine headache without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Divalproex Sodium.
    • Should I consume Divalproex Sodium empty stomach, before food or after food? website users have most commonly reported consuming Divalproex Sodium after food. However, this may not be reflective of how you should consume this medicine. Please follow your doctor's advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Divalproex Sodium.
    • Is it safe to drive or operate heavy machinery when consuming?
      If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Divalproex Sodium medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Divalproex Sodium. Always consult with your doctor for recommendations specific to your body and health conditions.
    • Is this medicine or product addictive or habit forming?
      Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
    • Can it be stopped immediately or do I have to slowly ween off consumption?
      Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

    Other important Information on Divalproex Sodium

    Missing a dose

    In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
    References: 1, 2, 3, 4

    Overdosage of Divalproex Sodium

    • Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Divalproex Sodium, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
    • Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
    • Please consult your physician or pharmacist or product package for more information.
    References: 5, 6, 7

    Storage of Divalproex Sodium

    • Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
    • Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Divalproex Sodium.
    References: 8, 9, 10, 11

    Expired Divalproex Sodium

    • Taking a single dose of expired Divalproex Sodium is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
    References: 12, 13

    Dosage Information

    Please consult your physician or pharmacist or refer to product package.

    Questions - Divalproex Sodium

    Like antipsychotics and antidepressants, an undesirable common side-effect associated with the use of some of the antiepileptic drugs is the gain in body weight.
     Article published in 2008 in Journal of Psychopharmacology had shown a weight gain of 57% in adults and 58% in older children and teenagers taking Divalproex. Studies suggest that patients taking carboxylic acids as antiepileptic medications may have an increase in serum insulin or glucose levels which may cause weight gain, possibly by stimulating appetite. But these weight changes may be reversible with intensive behavior therapy without discontinuation of carboxylic acids.
     An article published in Obesity Reviews showed up that patients receiving anti-epileptics increased their weight by an average of 4.41 pounds (2kgs) and ~11 pounds (5 kgs) in children with ~8.6 pounds (3.9kgs) as a mean weight gain.
     Carboxylic acids are not the only class of antiepileptics that may have side effects of weight gain. Other antiepileptics such as Cyclic GABA analogs (Gabapentin/Carbamazepine) may also cause weight gain.
     Patients concerned about weight gain or loss while taking Divalproex, should consult their healthcare provider or physician.
    1. Martin C, Han H, Anton S, Greenway F, Smith S. Effect of valproic acid on body weight, food intake, physical activity and hormones: results of a randomized controlled trial. Journal of psychopharmacology (Oxford, England) 2009;23(7):814-25. URL: 
    Share the link to this answer

    News and Updates

    Latest news and updates related to Divalproex Sodium. Subscribe to get latest posts via email or subscribe to a RSS feed.

    Wednesday, August 09, 2017 -- Results demonstrated that lithium was more effective in controlling manic signs and symptoms, as defined by a change from baseline Young Mania Rating Scale.

    Divalproex Sodium - Demographic Information


    1. - Accessed: July 14, 2016.
    2. - Accessed: July 3, 2016.
    3. Cancer.Net (2014). - Accessed: July 3, 2016.
    4. Schachter, S.C., Shafer, P. O. &; Sirven, J.I. (2013). - Accessed: May 28, 2016.
    5. National Institute of Drug Abuse (2010). - Accessed: July 21, 2016.
    6. eMedicinehealth (2016). - Accessed: July 21, 2016.
    7. Centers for Disease Control and Prevention (2010). - Accessed: July 21, 2016.
    8. Centers for Disease Control and Prevention. December 12, 2011. - Accessed: June 10, 2016.
    9. The Center for Improving Medication Management and the National Council on Patient Information and Education. - Accessed: June 10, 2016.
    10. U.S. Food and Drug Administration. December 24, 2013. - Accessed: June 10, 2016.
    11. World Health Organization: - Accessed: July 1, 2016.
    12. Lyon, R. C., Taylor, J. S., Porter, D. A., et al. (2006) Stability profiles of drug products extended beyond labeled expiration dates. Journal of Pharmaceutical Sciences; 95:1549-60 - Accessed: July 3, 2016.
    13. Harvard Medical School (2016). - Accessed: May 1, 2016.

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    Last updated date

    This page was last updated on 12/02/2017.
    This page provides information for Divalproex Sodium in English.
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