Thursday, January 18, 2018 -- A unique platform that resulted in a promising HIV vaccine has also led to a new, highly effective vaccine against tuberculosis that is moving toward testing in humans.
Monday, January 15, 2018 -- (Natural News) A study discovered that the ethanolic leaf extracts of the plant Rubia cordifolia or Indian madder contain anti-mycobacterial, cytotoxic, and antioxidant activities, which can be used in fighting against mycobacterial tuberculosis infection. A team of researchers from the University of Limpopo in South Africa analyzed the protective effects of Rubia cordifolia, more commonly known... Read More
Friday, January 12, 2018 -- Tuberculosis (TB), an infectious disease which attacks the lungs, claims someone's life every 20 seconds and 1.5 million lives worldwide every year.
Tuesday, January 09, 2018 -- Between February and November 2016, the Institute of Medical Microbiology at the University of Zurich discovered a multidrug-resistant Mycobacterium tuberculosis in eight refugees arriving in Europe from the Horn of Africa.
Monday, January 08, 2018 -- In The Lancet Infectious Diseases, Timothy Walker and colleagues1 report on a cluster of 29 multidrug-resistant tuberculosis cases among asylum seekers arriving in Europe from the Horn of Africa. They use whole-genome sequencing to identify the transmission links and describe the cross-border collaboration and control measures. Their study is of interest as it sheds light on the importance of early tuberculosis detection and highlights the potential of wide application of molecular epidemiology techniques.
Friday, January 05, 2018 -- A new study has found that anti-tuberculosis drugs killed more bacteria in laboratory mice given a vitamin C supplement than those given drugs alone. If the findings hold up in human studies, the authors say, the result could be that there's a cheap, safe way to reduce the months-long treatment time for one of the world's leading killers. Also, the vitamin supplement could offer a way to cut down on the development of drug-resistant TB, a serious health threat. Tuberculosis is one of the leading causes of death worldwide. According to the World Health Organization, 1.7 million people died of the disease last year. Of more than 10 million new infections, about 600,000 were resistant to the leading drug. Front-line
Monday, January 01, 2018 -- An X-ray of the lung of a suspected tuberculosis patient in Vietnam. Researchers say urine testing for tuberculosis, which kills 1.7 million people a year, may soon be possible.
Thursday, December 21, 2017 -- Future development strategies should focus on antibiotics that are active against multidrug-resistant tuberculosis and Gram-negative bacteria. The global strategy should include antibiotic-resistant bacteria responsible for community-acquired infections such as Salmonella spp, Campylobacter spp, N gonorrhoeae, and H pylori.
Wednesday, December 13, 2017 -- by Bindu Singh, Mohd Saqib, Ananya Gupta, Pawan Kumar, Sangeeta Bhaskar Mycobacterium indicus pranii (MIP) is a potent vaccine candidate against tuberculosis (TB) as it has demonstrated significant protection in animal models of tuberculosis as well as in clinical trials. Higher protective efficacy of MIP against TB as compared to BCG provoked the efforts to gain insight into the molecular mechanisms underlying MIP mediated protection against Mycobacterium tuberculosis (M.tb). Autophagy, initially described as a cell survival mechanism during starvation, also plays a key role in host resistance to M.tb. Virulent mycobacteria like M.tb, suppresses host autophagy response to increase its survival in macrophages. Since mycobacterial species have been shown to vary widely in their autophagy-inducing properties, in the present
Wednesday, December 13, 2017 -- Sometimes projects don’t work the way you want or need them to the first time, and as the saying goes, if at first you don’t succeed, try, try again. The Global Good Fund, a collaboration... View the entire article via our website.
Wednesday, December 13, 2017 -- An accurate urine test for pulmonary tuberculosis (TB), affecting 9.6 million patients worldwide, is critically needed for surveillance and treatment management. Past attempts failed to reliably detect the mycobacterial glycan antigen lipoarabinomannan (LAM), a marker of active TB, in HIV-negative, pulmonary TB–infected patients’ urine (85% of 9.6 million patients). We apply a copper complex dye within a hydrogel nanocage that captures LAM with very high affinity, displacing interfering urine proteins. The technology was applied to study pretreatment urine from 48 Peruvian patients, all negative for HIV, with microbiologically confirmed active pulmonary TB. LAM was quantitatively measured in the urine with a sensitivity of >95% and a specificity of >80% (n = 101) in a concentration range of 14 to
Tuesday, December 12, 2017 -- Tuberculosis is one of the most widespread life-threatening infectious diseases. Not only does antibiotic resistance make treatment increasingly difficult, but the bacteria’s relatively impermeable mycomembrane also limits the effectiveness of many drugs.
Wednesday, December 06, 2017 -- Despite centuries of scientific endeavour and social struggle, tuberculosis continues to claim more than 1·6 million lives each year.1 Tuberculosis has killed and continues to kill more people than any other infectious disease. In The Lancet Infectious Diseases, the GBD Tuberculosis Collaborators2 estimate that 10·2 million (95% uncertainty interval [95% UI] 9·2 million to 11·5 million) individuals developed tuberculosis in 2015. While this estimate represents a modest decline since peaking in the early years of this century, the continued high burden, along with a woefully inadequate response to drug-resistant tuberculosis,1 show a profound failure of public health globally.
Wednesday, December 06, 2017 -- Despite a concerted global effort to reduce the burden of tuberculosis, it still causes a large disease burden globally. Strengthening of health systems for early detection of tuberculosis and improvement of the quality of tuberculosis care, including prompt and accurate diagnosis, early initiation of treatment, and regular follow-up, are priorities. Countries with higher than expected tuberculosis rates for their level of sociodemographic development should investigate the reasons for lagging behind and take remedial action.
Wednesday, December 06, 2017 -- by Robert J. Flick, Adamson Munthali, Katherine Simon, Mina Hosseinipour, Maria H. Kim, Lameck Mlauzi, Peter N. Kazembe, Saeed Ahmed Transmission of Mycobacterium tuberculosis (TB) in health settings threatens health care workers and people living with HIV in sub-Saharan Africa. Nosocomial transmission is reduced with implementation of infection control (IC) guidelines. The objective of this study is to describe implementation of TB IC measures in Malawi. We conducted a cross-sectional study utilizing anonymous health worker questionnaires, semi-structured interviews with facility managers, and direct observations at 17 facilities in central Malawi. Of 592 health care workers surveyed, 34% reported that all patients entering the facility were screened for cough and only 8% correctly named the four most common signs and
Friday, December 01, 2017 -- A new study provides data on the “know-do” and “policy-practice” gaps found in tuberculosis diagnosis and care across three levels of China’s health system. What is Tuberculosis? Tuberculosis, or TB, is a disease caused by bacteria called Mycobacterium tuberculosis. A tuberculosis diagnosis includes detecting symptoms of fever, night sweats, coughing, hemoptysis (coughing up sputum stained […] The post Tuberculosis Diagnosis and Care in China: A Lesson for All appeared first on Medical News Bulletin | Health News and Medical Research.
Thursday, November 30, 2017 -- For tuberculosis case detection, sensitivity of Xpert Ultra was superior to that of Xpert in patients with paucibacillary disease and in patients with HIV. However, this increase in sensitivity came at the expense of a decrease in specificity.
Monday, November 27, 2017 -- In a recent study, researchers investigate whether there is an association between poorly controlled diabetes and tuberculosis. For centuries, healthcare providers have recognized that there is an association between diabetes and tuberculosis. In fact, patients with diabetes are considered to have a higher potential risk of developing tuberculosis (TB). The reason for this being that […] The post What is the Relationship between Diabetes and Tuberculosis? appeared first on Medical News Bulletin | Health News and Medical Research.
Monday, November 27, 2017 -- Researchers in South Africa have developed a symptom score card to help diagnose tuberculosis infections in individuals with HIV.
Thursday, November 23, 2017 -- In our cohort, mortality was high in the first 6 months after suspicion of tuberculosis in ART-naive children. ART should be started early, particularly in children with factors associated with high mortality. Documented or empirical tuberculosis treatment decision should be accelerated to reduce mortality and allow early ART initiation.