Tuesday, January 16, 2018 -- Johns Hopkins hopes to become the first hospital in the U.S. to perform HIV-positive to HIV-positive organ transplants from living donors.
Thursday, January 18, 2018 -- The ability of HIV to mutate has been a major challenge to vaccine development. As the body produces antibodies to target the outer HIV envelope protein, this protein changes, thwarting the circulating antibodies' ability to neutralize it.
Tuesday, January 16, 2018 -- A new study that seeks to ascertain HIV mortality rates in Zambia could provide a model for improved national and regional surveillance approaches and, ultimately, more effective HIV treatment strategies.
Thursday, January 18, 2018 -- by Todd M. Pollack, Hao T. Duong, Phuong T. Truong, Thuy T. Pham, Cuong D. Do, Donn Colby The use of dried blood spot (DBS) specimens for HIV viral load (VL) monitoring is recommended to support the roll-out of routine VL monitoring in low and middle income countries (LMICs). To better understand the use of DBS for VL monitoring, we evaluated two DBS testing methods, Roche TaqMan® Free Virus Evolution protocol (DBS-FVE) and Roche TaqMan® SPEX protocol (DBS-SPEX)) in patients receiving ART at an HIV clinic in Hanoi, Vietnam. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for each DBS testing method at the thresholds of 1000 and 5000 copies/ml compared to plasma VL.
Sunday, January 14, 2018 -- When people started to show up to Dr. William Cooke's primary care office in Austin, Ind., in 2014 with HIV, Cooke knew it was probably related to the region's opioid epidemic. But what he and the rest of the public health community didn't know was who they were missing or how long the HIV outbreak had been going on. Now they've got a clearer picture — literally. In visualizations published in the Journal of Infectious Diseases, dots and lines define the constellations of Indiana's HIV outbreak. Using genetic sequencing, they show how long the outbreak had been going on, connected people who hadn't previously been linked by traditional methods, and showed how the virus jumped from a slowly
Thursday, January 18, 2018 -- A new article urges researchers and clinicians to consider the possibility that the rise in oral sex practices could ultimately contribute to female infertility when it comes to chlamydia.
Monday, January 15, 2018 -- Teva Pharmaceuticals announces an exclusive launch of a generic version of atazanavir capsules for the treatment of HIV.
Wednesday, January 17, 2018 -- Chronic pain is increasingly recognized as an important comorbidity of HIV-infected patients, however, the exact molecular mechanisms of HIV-related pain are still elusive. CCAAT/enhancer binding proteins (C/EBPs) are expressed in various tissues, including the CNS. C/EBPβ, one of the C/EBPs, is involved in the progression of HIV/AIDS, but the exact role of C/EBPβ and its upstream factors are not clear in HIV pain state. Here, we used a neuropathic pain model of perineural HIV envelope glycoprotein gp120 application onto the rat sciatic nerve to test the role of phosphorylated C/EBPβ (pC/EBPβ) and its upstream pathway in the spinal cord dorsal horn (SCDH). HIV gp120 induced overexpression of pC/EBPβ in the ipsilateral SCDH compared with contralateral SCDH. Inhibition of C/EBPβ
Thursday, January 18, 2018 -- MedicalResearch.com Interview with: Tae-Wook Chun, Ph.D. National Institutes of Health Bethesda, MD 20892 MedicalResearch.com: What is the background for this study? What are the main findings? Response: While antiretroviral therapy (ART) has improved the clinical outcome for people living with … Continue reading →
Tuesday, January 16, 2018 -- Conflict in Ukraine has increased the risk of HIV outbreaks throughout the country as displaced HIV-infected people move from war-affected regions to areas with higher risk of transmission, according to analysis by scientists.
Tuesday, January 16, 2018 -- Fighting in Ukraine that erupted in 2014 escalated the spread of HIV throughout the country as millions of infected people were uprooted by violence, a study published Monday found. Conflict-affected areas such as Donetsk and Luhansk, two large cities in the east of Ukraine, were the main exporters of the HIV virus to other parts of the country such as Kyiv and Odessa, the report found. Ukraine has among the highest HIV rates in Europe, with an estimated 220,000 infected in a country of about 45 million. An international team of scientists led by Oxford University and Public Health England analyzed viral migration patterns and found a correlation between the war-related movement of 1.7 million people and the spread