Monday, January 08, 2018 -- This follows the extension of a QUT collaboration with Johnson & Johnson Innovation, Janssen Vaccines & Prevention, and Janssen Cilag Pty Ltd.
Thursday, January 11, 2018 -- by Joseph G. Skeate, Diane M. Da Silva, Elena Chavez-Juan, Snjezana Anand, Richard Nuccitelli, W. Martin Kast Nano-Pulse Stimulation (NPS) is a non-thermal pulsed electric field modality that has been shown to have cancer therapeutic effects. Here we applied NPS treatment to the human papillomavirus type 16 (HPV 16)-transformed C3.43 mouse tumor cell model and showed that it is effective at eliminating primary tumors through the induction of immunogenic cell death while subsequently increasing the number of tumor-infiltrating lymphocytes within the tumor microenvironment. In vitro NPS treatment of C3.43 cells resulted in a doubling of activated caspase 3/7 along with the translocation of phosphatidylserine (PS) to the outer leaflet of the plasma membrane, indicating programmed cell death activity. Tumor-bearing
Thursday, January 11, 2018 -- Certain head and neck cancers that are positive for high-risk types of human papillomavirus (HPV) have a better prognosis and may need less aggressive treatment.