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    Thursday, August 31, 2017 -- As people with Down syndrome live longer, a new analysis suggests that this population is growing, but that may not hold true for long.

    Thursday, December 14, 2017 -- CLEVELAND (Reuters) - Women in Ohio would be prohibited from receiving abortions because of a fetal Down syndrome diagnosis under a bill that passed the state senate on Wednesday and is heading to Republican Governor John Kasich’s desk.

    Wednesday, August 16, 2017 -- REYKJAVIK, ICELAND — Iceland is on the verge of completely eliminating Down syndrome. According to a CBS report, just one or two children with Down syndrome are born in Iceland per year. How you ask? Through abortion. You see, prenatal testing is optional, but doctors are required to tell women that it is an option by law. Of the women who choose to take the test, close to 100 percent terminate their pregnancy if the results come back positive for […]

    Thursday, November 30, 2017 -- (Reuters Health) - Pregnant women may get accurate screening results for Down syndrome – also known as trisomy 21 - and two rarer chromosomal disorders with a finger-prick blood test that reduces the need for more invasive diagnostic procedures, a UK study suggests.

    Thursday, June 01, 2017 -- A phase 2 clinical trial in young adults with Down syndrome of a drug being investigated for the treatment of Alzheimer's disease supports further investigation of its potential.

    Tuesday, November 21, 2017 -- Some scientists call it the "final frontier" of our DNA -- even though it lies at the center of every X-shaped chromosome in nearly every one of our cells.

    Wednesday, November 22, 2017 -- by Claire Enea-Drapeau, Michèle Carlier, Pascal Huguet Studies over the past three decades have shown that learning difficulties are not only determined by neurological disorders, but also by motivational and/or socio-cognitive factors Among these factors, implicit theories of intelligence (also referred to as conceptions, mindsets or beliefs about intelligence) are key elements. The belief that intelligence is fixed (entity theory), as opposed to malleable (incremental theory), is generally associated with negative teaching practices and poorer student outcomes, yet beliefs about the intelligence of individuals with intellectual disabilities have not received much attention. We propose the first study on conceptions of intelligence of persons with intellectual disabilities, here people with Down syndrome. Participants were 55 professionally qualified people working with

    Friday, December 15, 2017 -- by Monika Zbucka-Kretowska, Karol Charkiewicz, Joanna Goscik, Slawomir Wolczynski, Piotr Laudanski Objective and design Angiogenic factors are proteins that are related to certain foetal chromosomal abnormalities. The aim of this study was to determine the concentration of 60 angiogenic factors in the plasma of women with offspring possessing trisomy 21/Down syndrome (DS). Method After analysing karyotyping results, we selected 20 patients with foetuses possessing DS, and for the control group, we selected 28 healthy patients with uncomplicated pregnancies who delivered healthy newborns at term (i.e., 15–18 weeks of gestation). To assess the concentration of proteins in the blood plasma, we used a protein macroarray which enabled simultaneous determination of 60 angiogenic factors per sample. Results We observed a statistically

    Thursday, November 16, 2017 -- COLUMBUS, Ohio (AP) - The Ohio Senate has passed legislation that would make it a crime for a doctor to perform an abortion if the fetus might have Down syndrome.The Dispatch reports the Senate on Wednesday passed the legislation by a 20-12 vote. It makes

    Thursday, June 22, 2017 -- Patients with myeloid leukemia of Down syndrome (ML-DS) have favorable event-free survival (EFS), but experience significant treatment-related morbidity and mortality. ML-DS blast cells ex vivo have increased sensitivity to cytarabine (araC) and daunorubicin, suggesting that optimizing drug dosing may improve outcomes while reducing toxicity. The Children’s Oncology Group (COG) AAML0431 trial consisted of 4 cycles of induction and 2 cycles of intensification therapy based on the treatment schema of the previous COG A2971 trial with several modifications. High-dose araC (HD-araC) was used in the second induction cycle instead of the intensification cycle, and 1 of 4 daunorubicin-containing induction cycles was eliminated. For 204 eligible patients, 5-year EFS was 89.9% and overall survival (OS) was 93.0%. The 5-year OS for

    Thursday, June 22, 2017 -- Children with myeloid leukemia associated with Down syndrome (ML-DS) have superior outcome compared with non-DS patients, but suffer from higher constitutional cytotoxic drug susceptibility. We analyzed the outcome of 170 pediatric patients with ML-DS enrolled in the prospective, multicenter, open-label, nonrandomized ML-DS 2006 trial by Nordic Society for Pediatric Hematology and Oncology (NOPHO), Dutch Childhood Oncology Group (DCOG), and Acute Myeloid Leukemia–Berlin-Frankfurt-Münster (AML-BFM) study group. Compared with the historical control arm (reduced-intensity protocol for ML-DS patients from the AML-BFM 98 trial), treatment intensity was reduced by lowering the cumulative dose of etoposide (950 to 450 mg/m2) and intrathecal central nervous system prophylaxis while omitting maintenance therapy. Still, 5-year overall survival (89% ± 3% vs 90% ± 4%; Plog-rank =

    Tuesday, June 06, 2017 -- A phase 2 clinical trial in young adults with Down syndrome of a drug being investigated for the treatment of Alzheimer’s disease supports further investigation of its potential. Results of the four-week trial of scyllo-inositol, also known as ELND005, have been published in the Journal of Alzheimer’s Disease.

    Wednesday, October 11, 2017 -- Activity-dependent synaptic plasticity plays a critical role in the refinement of circuitry during postnatal development and may be disrupted in conditions that cause intellectual disability, such as Down syndrome (DS). To test this hypothesis, visual cortical plasticity was assessed in Ts65Dn mice that harbor a chromosomal duplication syntenic to human chromosome 21q. We find that Ts65Dn mice demonstrate a defect in ocular dominance plasticity (ODP) following monocular deprivation. This phenotype is similar to that of transgenic mice that express amyloid precursor protein (APP), which is duplicated in DS and in Ts65DN mice; however, normalizing APP gene copy number in Ts65Dn mice fails to rescue plasticity. Ts1Rhr mice harbor a duplication of the telomeric third of the Ts65Dn-duplicated sequence and

    Tuesday, December 26, 2017 -- DENVER, Dec. 26, 2017 -- A groundbreaking new study conducted by the Crnic Institute for Down Syndrome shows definitively that Down syndrome can be categorized as an immune system disorder, based on analyses of...

    Thursday, June 08, 2017 -- Down syndrome is a common genetic disorder that is associated with a multitude of diseases and disorders. In a recent study published in PLOS ONE, the authors seek to find differences in the micronutrients of people with Down syndrome.   Down syndrome is a widely known congenital condition caused by an extra copy of chromosome […] The post Micronutrients: Predicting Diseases Associated in People with Down Syndrome appeared first on Medical News Bulletin.

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