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    What is Espazine Plus?

    Espazine Plus Tablet is used for Depression, Emotional instability, Nausea, Vomiting, Parkinsonism, Drug induced extrapyramidal movement disorders and other conditions. Espazine Plus Tablet may also be used for purposes not listed in this medication guide.
    Espazine Plus Tablet contains Benzhexol and Trifluoperazine as active ingredients.
    Espazine Plus Tablet works by decreasing the activity of neurotransmitter that causes excitation of brain cells; binding and inhibiting the M1 muscarinic receptor and the dopamine receptor;
    GlaxoSmithKline Pharmaceuticals manufactures Espazine Plus Tablet.
    Detailed information related to Espazine Plus Tablet's uses, composition, dosage, side effects and reviews is listed below.

    Espazine Plus Tablet Uses

    Espazine Plus Tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
    References: 1, 2
    Learn more: Uses

    Espazine Plus Tablet Working, Mechanism of Action and Pharmacology

    Espazine Plus Tablet improves the patient's condition by performing the following functions:
    References: 3, 4, 5

    Espazine Plus Tablet - Composition and Active Ingredients

    Espazine Plus Tablet is composed of the following active ingredients (salts)
    Please note that this medicine may be available in various strengths for each active ingredient listed above.

    Espazine Plus Tablet - Side-effects

    The following is a list of possible side-effects that may occur from all constituting ingredients of Espazine Plus Tablet. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
    If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
    References: 1, 2
    Learn more: Side-effects

    Espazine Plus Tablet - Precautions & How to Use

    Before using Espazine Plus Tablet, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
    • Arteriosclerosis
    • Avoid alcohol and other central nervous system depressants
    • Consult your doctor immediately if gastrointestinal problems, fever, or heat intolerance develop
    • Consult your doctor in case you suffer from heart or blood vessel disease, history of blood clotting problems, suffering from parkinson's disease, epilepsy, glaucoma, myasthenia gravis, loss of memory function, changes in body temperature, intestinal obstruction, cardiovascular disease, pheochromocytoma, brain damage, benign prostatic hyperplasia
    • Do not consume alcohol
    • Do not discontinue without consulting your doctor first
    References: 1, 1, 2, 2

    Espazine Plus Tablet - Drug Interactions

    If you use other drugs or over the counter products at the same time, the effects of Espazine Plus Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Espazine Plus Tablet may interact with the following drugs and products:
    • Adrenaline
    • Alcohol
    • Barbiturates
    • Cannabinoids
    • Central nervous system depressants
    • Guanethidine
    References: 1, 2
    Learn more: Interactions

    Espazine Plus Tablet - Contraindications

    Hypersensitivity to Espazine Plus Tablet is a contraindication. In addition, Espazine Plus Tablet should not be used if you have the following conditions:
    • Blood dyscrasias
    • Children below age of six years
    • Coma
    • Hepatic or renal impairment
    • Hypersensitivity
    • Lactation
    References: 1, 2
    Learn more: Contraindications

    Where to Buy Espazine Plus Tablet

    Click here to find nearby pharmacies/medical stores where you can buy Espazine Plus Tablet.

    Espazine Plus Tablet - Frequently asked Questions

    • Is Espazine Plus Tablet safe to consume or apply when pregnant?
      • Trifluoperazine: No
      • Benzhexol: Please consult with your doctor for case-specific recommendations.
      References: 1 2
    • Is Espazine Plus Tablet safe while breastfeeding?
      • Trifluoperazine: No
      • Benzhexol: Please discuss the risks and benefits with your doctor.
      References: 1 2
    • Can Espazine Plus Tablet be used for depression and emotional instability?
      Yes, depression and emotional instability are among the most common reported uses for Espazine Plus Tablet. Please do not use Espazine Plus Tablet for depression and emotional instability without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Espazine Plus Tablet.
    • How long do I need to use Espazine Plus Tablet before I see improvement of my conditions? website users have reported 3 days and same day as the most common time it takes before they saw improvements in their conditions. These times may not be reflective of what you may experience or how you should use this medicine. Please consult with your doctor to check how long do you need to use Espazine Plus Tablet. Click here and view survey results to find out what other patients report as time for effectiveness for Espazine Plus Tablet.
    • At what frequency do I need to use Espazine Plus Tablet? website users have reported once a day and twice a day as the most common frequency of using Espazine Plus Tablet. Please follow your doctor's advice on how often you need to Espazine Plus Tablet. Click here and view survey results to find out what other patients report as frequency of using Espazine Plus Tablet.
    • Should I consume Espazine Plus Tablet empty stomach, before food or after food? website users have most commonly reported consuming Espazine Plus Tablet after food. However, this may not be reflective of how you should consume this medicine. Please follow your doctor's advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Espazine Plus Tablet.
    • Is it safe to drive or operate heavy machinery when consuming?
      If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Espazine Plus Tablet medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Espazine Plus Tablet. Always consult with your doctor for recommendations specific to your body and health conditions.
    • Is this medicine or product addictive or habit forming?
      Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
    • Can it be stopped immediately or do I have to slowly ween off consumption?
      Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

    Other important Information on Espazine Plus Tablet

    Missing a dose

    In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
    References: 6, 7, 8, 9

    Overdosage of Espazine Plus Tablet

    • Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Espazine Plus Tablet, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
    • Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
    • Please consult your physician or pharmacist or product package for more information.
    References: 10, 11, 12

    Storage of Espazine Plus Tablet

    • Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
    • Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Espazine Plus Tablet.
    References: 13, 14, 15, 16

    Expired Espazine Plus Tablet

    • Taking a single dose of expired Espazine Plus Tablet is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
    References: 17, 18

    Dosage Information

    Please consult your physician or pharmacist or refer to product package.

    Questions - Espazine Plus Tablet

    No questions have been asked.

    News and Updates

    Latest news and updates related to Espazine Plus Tablet. Subscribe to get latest posts via email or subscribe to a RSS feed.
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    Espazine Plus Tablet - Packages and Strengths

    Espazine Plus Tablet is available in the following packages and strengths
    Espazine Plus Tablet - Packages: 10 Tablet
    Espazine Plus Tablet - Strengths: 5MG+2MG

    Espazine Plus Tablet - Manufacturers

    The medicine is manufactured by the following companies

    Espazine Plus Tablet - Demographic Information


    1. Dailymed - Accessed: October 12, 2016.
    2. Dailymed label: Trihexyphenidyl hydrochloride. . - Accessed: October 12, 2016. Accessed September 29, 2016.
    3. Giachetti, A.; Giraldo, E.; Ladinsky, H.; Montagna, E. (1986). "Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine". British Journal of Pharmacology. 89 (1): 83–90. doi:10.1111/j.1476-5381.1986.tb11123.x. PMC 1917044 PMID 2432979. - Accessed: October 12, 2016.
    4. - Accessed: October 12, 2016.
    5. Berke, J. D.; Hyman, S. E. (2000). "Addiction, dopamine, and the molecular mechanisms of memory". Neuron. 25 (3): 515–532. doi:10.1016/S0896-6273(00)81056-9. PMID 10774721. - Accessed: October 12, 2016.
    6. - Accessed: July 14, 2016.
    7. - Accessed: July 3, 2016.
    8. Cancer.Net (2014). - Accessed: July 3, 2016.
    9. Schachter, S.C., Shafer, P. O. &; Sirven, J.I. (2013). - Accessed: May 28, 2016.
    10. National Institute of Drug Abuse (2010). - Accessed: July 21, 2016.
    11. eMedicinehealth (2016). - Accessed: July 21, 2016.
    12. Centers for Disease Control and Prevention (2010). - Accessed: July 21, 2016.
    13. Centers for Disease Control and Prevention. December 12, 2011. - Accessed: June 10, 2016.
    14. The Center for Improving Medication Management and the National Council on Patient Information and Education. - Accessed: June 10, 2016.
    15. U.S. Food and Drug Administration. December 24, 2013. - Accessed: June 10, 2016.
    16. World Health Organization: - Accessed: July 1, 2016.
    17. Lyon, R. C., Taylor, J. S., Porter, D. A., et al. (2006) Stability profiles of drug products extended beyond labeled expiration dates. Journal of Pharmaceutical Sciences; 95:1549-60 - Accessed: July 3, 2016.
    18. Harvard Medical School (2016). - Accessed: May 1, 2016.

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    APA Style Citation

    • Espazine Plus Tablet - Uses, Side-effects, Reviews, and Precautions - GlaxoSmithKline Pharmaceuticals - - India. (n.d.). Retrieved March 14, 2018, from

    MLA Style Citation

    • "Espazine Plus Tablet - Uses, Side-effects, Reviews, and Precautions - GlaxoSmithKline Pharmaceuticals - - India" N.p., n.d. Web. 14 Mar. 2018.

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    • "Espazine Plus Tablet - Uses, Side-effects, Reviews, and Precautions - GlaxoSmithKline Pharmaceuticals - - India" Accessed March 14, 2018.

    Last updated date

    This page was last updated on 12/17/2017.
    This page provides information for Espazine Plus Tablet in English.
    Read Reviews » Espazine Plus Tablet

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