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    What is Closis Plus?

    Closis Plus Tablet is used for Treatment of seizure disorder, Treatment of panic disorder, Hypertension, Fast heart beat, Migraine and other conditions. Closis Plus Tablet may also be used for purposes not listed in this medication guide.
    Closis Plus Tablet contains Clonazepam and Propranolol as active ingredients.
    Closis Plus Tablet works by enhancing the activity of gamma aminobutyric acid (GABA) neurotransmitter; blocking the action of histamine;
    Intel Pharma manufactures Closis Plus Tablet.
    Detailed information related to Closis Plus Tablet's uses, composition, dosage, side effects and reviews is listed below.

    Closis Plus Tablet Uses

    Closis Plus Tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
    References: 1, 2, 3, 4, 5, 6, 7, 8
    Learn more: Uses

    Closis Plus Tablet Working, Mechanism of Action and Pharmacology

    Closis Plus Tablet improves the patient's condition by performing the following functions:
    References: 1, 2, 3, 4, 5, 6, 7, 8

    Closis Plus Tablet - Composition and Active Ingredients

    Closis Plus Tablet is composed of the following active ingredients (salts)
    Please note that this medicine may be available in various strengths for each active ingredient listed above.

    Closis Plus Tablet - Side-effects

    The following is a list of possible side-effects that may occur from all constituting ingredients of Closis Plus Tablet. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
    If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
    References: 1, 2, 3, 4, 5, 6, 7, 8
    Learn more: Side-effects

    Closis Plus Tablet - Precautions & How to Use

    Before using Closis Plus Tablet, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
    • Avoid abrupt discontinuation of this drug
    • Avoid alcohol
    • Avoid driving
    • Avoid getting up too fast from a sitting or lying position
    • Check blood pressure and heart rate as directed by doctor
    • Check your blood pressure after one week and consult your doctor if it has not improved
    References: 1, 1, 2, 2, 3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8

    Closis Plus Tablet - Drug Interactions

    If you use other drugs or over the counter products at the same time, the effects of Closis Plus Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Closis Plus Tablet may interact with the following drugs and products:
    • Alcohol
    • Aluminum hydroxide
    • Antianxiety agents
    • Anticonvulsant drugs
    • Atropine
    • Barbiturates
    References: 1, 2, 3, 4, 5, 6, 7, 8
    Learn more: Interactions

    Closis Plus Tablet - Contraindications

    Hypersensitivity to Closis Plus Tablet is a contraindication. In addition, Closis Plus Tablet should not be used if you have the following conditions:
    • Acute myocardial infarction
    • Acute narrow angle glaucoma
    • Alcohol
    • Cardiogenic shock
    • Chronic obstructive pulmonary disease
    • Congestive heart failure
    References: 1, 2, 3, 4, 5, 6, 7, 8
    Learn more: Contraindications

    Where to Buy Closis Plus Tablet

    Click here to find nearby pharmacies/medical stores where you can buy Closis Plus Tablet.

    Closis Plus Tablet - Frequently asked Questions

    • Is Closis Plus Tablet safe to consume or apply when pregnant?
      • Clonazepam: No
      • Propranolol: Please consult with your doctor for case-specific recommendations.
      References: 1 2 3 4 5 6 7 8
    • Is Closis Plus Tablet safe while breastfeeding?
      • Clonazepam: No
      • Propranolol: Please discuss the risks and benefits with your doctor.
      References: 1 2 3 4 5 6 7 8
    • Is it safe to drive or operate heavy machinery when consuming?
      If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Closis Plus Tablet medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Closis Plus Tablet. Always consult with your doctor for recommendations specific to your body and health conditions.
    • Is this medicine or product addictive or habit forming?
      Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
    • Can it be stopped immediately or do I have to slowly ween off consumption?
      Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

    Other important Information on Closis Plus Tablet

    Missing a dose

    In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
    References: 9, 10, 11, 12

    Overdosage of Closis Plus Tablet

    • Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Closis Plus Tablet, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
    • Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
    • Please consult your physician or pharmacist or product package for more information.
    References: 13, 14, 15

    Storage of Closis Plus Tablet

    • Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
    • Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Closis Plus Tablet.
    References: 16, 17, 18, 19

    Expired Closis Plus Tablet

    • Taking a single dose of expired Closis Plus Tablet is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
    References: 20, 21

    Dosage Information

    Please consult your physician or pharmacist or refer to product package.

    Questions - Closis Plus Tablet

    No questions have been asked.

    News and Updates

    Latest news and updates related to Closis Plus Tablet. Subscribe to get latest posts via email or subscribe to a RSS feed.
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    Closis Plus Tablet - Packages and Strengths

    Closis Plus Tablet is available in the following packages and strengths
    Closis Plus Tablet - Packages: 10 Tablet

    Closis Plus Tablet - Manufacturers

    The medicine is manufactured by the following companies

    Closis Plus Tablet - Demographic Information


    1. Accessed on 11/14/2016. DailyMed LABEL: CLONAZEPAM- clonazepam tablet - Accessed: October 12, 2016.
    2. DailyMed LABEL: PROPRANOLOL- propranolol hydrochloride injection, solution - Accessed: October 12, 2016.
    3. Steenen, SA; van Wijk, AJ; van der Heijden, GJ; van Westrhenen, R; de Lange, J; de Jongh, A (February 2016). "Propranolol for the treatment of anxiety disorders: Systematic review and meta-analysis.". Journal of psychopharmacology (Oxford, England). 30 (2): 128_39. doi:10.115612236. PMC 4724794free to read. PMID 26487439. - Accessed: October 12, 2016.
    4. Thibaut F, Colonna L (1993). "[Anti-aggressive effect of beta-blockers]". L'Enc_phale (in French). 19 (3): 263_7. PMID 7903928. - Accessed: October 12, 2016.
    5. Vieweg V, Pandurangi A, Levenson J, Silverman J (1994). "The consulting psychiatrist and the polydipsia-hyponatremia syndrome in schizophrenia". International Journal of Psychiatry in Medicine. 24 (4): 275_303. doi:10.2190/5WG5-VV1V-BXAD-805K. PMID 7737786. - Accessed: October 12, 2016.
    6. Kishi Y, Kurosawa H, Endo S (1998). "Is propranolol effective in primary polydipsia?". International Journal of Psychiatry in Medicine. 28 (3): 315_25. doi:10.2190/QPWL-14H7-HPGG-A29D. PMID 9844835. - Accessed: October 12, 2016.
    7. Shields, Kevin G.; Peter J. Goadsby (January 2005). "Propranolol modulates trigeminovascular responses in thalamic ventroposteromedial nucleus: a role in migraine?". Brain. 128 (1): 86_97. doi:10.1093/brain/awh298. Retrieved 16 September 2016. - Accessed: October 12, 2016.
    8. Eadie, M.; J. H. Tyrer (1985). The Biochemistry of Migraine. New York: Springer. p. 148. ISBN 0. OCLC 11726870. - Accessed: October 12, 2016. (Accessed on 2/6/17)
    9. - Accessed: July 14, 2016.
    10. - Accessed: July 3, 2016.
    11. Cancer.Net (2014). - Accessed: July 3, 2016.
    12. Schachter, S.C., Shafer, P. O. &; Sirven, J.I. (2013). - Accessed: May 28, 2016.
    13. National Institute of Drug Abuse (2010). - Accessed: July 21, 2016.
    14. eMedicinehealth (2016). - Accessed: July 21, 2016.
    15. Centers for Disease Control and Prevention (2010). - Accessed: July 21, 2016.
    16. Centers for Disease Control and Prevention. December 12, 2011. - Accessed: June 10, 2016.
    17. The Center for Improving Medication Management and the National Council on Patient Information and Education. - Accessed: June 10, 2016.
    18. U.S. Food and Drug Administration. December 24, 2013. - Accessed: June 10, 2016.
    19. World Health Organization: - Accessed: July 1, 2016.
    20. Lyon, R. C., Taylor, J. S., Porter, D. A., et al. (2006) Stability profiles of drug products extended beyond labeled expiration dates. Journal of Pharmaceutical Sciences; 95:1549-60 - Accessed: July 3, 2016.
    21. Harvard Medical School (2016). - Accessed: May 1, 2016.

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    • Closis Plus Tablet - Uses, Side-effects, Reviews, and Precautions - Intel Pharma - - India. (n.d.). Retrieved March 18, 2018, from

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    Last updated date

    This page was last updated on 6/23/2017.
    This page provides information for Closis Plus Tablet in English.
    Read Reviews » Closis Plus Tablet

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